Structure of PDB 1r55 Chain A Binding Site BS02

Receptor Information
>1r55 Chain A (length=203) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TRKYLELYIVADHTLFLTRHRNLQHTKQRLLEVANYVDQLLRTLDIQVAL
TGLEVWTERDRSRVTQDANATLWAFLQWRRGLWAQRPHDSAQLLTGRAFQ
GATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDP
DGCCVEAAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSN
APS
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain1r55 Chain A Residue 515 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1r55 Crystal structre of the catalytic domain of human ADAM33
Resolution1.58 Å
Binding residue
(original residue number in PDB)		E213 D296 C404 N407
Binding residue
(residue number reindexed from 1)		E6 D89 C197 N200
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.24.-
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008237 metallopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:1r55, PDBe:1r55, PDBj:1r55
PDBsum1r55
PubMed14659745
UniProtQ9BZ11|ADA33_HUMAN Disintegrin and metalloproteinase domain-containing protein 33 (Gene Name=ADAM33)

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