Structure of PDB 1ql6 Chain A Binding Site BS02

Receptor Information

>1ql6 Chain A (length=281) Species: 9986 (Oryctolagus cuniculus)

STHGFYENYEPKEILGRGVSSVVRRCIHKPTCKEYAVKIIDVTGGGSFSA
EEVQELREATLKEVDILRKVSGHPNIIQLKDTYETNTFFFLVFDLMKKGE
LFDYLTEKVTLSEKETRKIMRALLEVICALHKLNIVHRDLKPENILLDDD
MNIKLTDFGFSCQLDPGEKLRSVCGTPSYLAPEIIECSMNDNHPGYGKEV
DMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMSGNYQFGSPEWDDYSDTV
KDLVSRFLVVQPQKRYTAEEALAHPFFQQYV

Ligand information

• Ligand ID: MN
• InChI: InChI=1S/Mn/q+2
• InChIKey: WAEMQWOKJMHJLA-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mn+2]
  CACTVS 3.341: [Mn++]
• Formula: Mn
• Name: MANGANESE (II) ION
• DrugBank: DB06757
• PDB chain: 1ql6 Chain A Residue 303

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1ql6 Catalytic Mechanism of Phosphorylase Kinase Probed by Mutational Studies.
• Resolution: 2.4 Å
• Binding residue (original residue number in PDB): N154 D167
• Binding residue (residue number reindexed from 1): N144 D157
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): D149 K151 N154 D167 T186
• Catalytic site (residue number reindexed from 1): D139 K141 N144 D157 T176
• Enzyme Commision number: 2.7.11.1: non-specific serine/threonine protein kinase.
  2.7.11.19: phosphorylase kinase.
  2.7.11.26: [tau protein] kinase.

Gene Ontology

Molecular Function

• GO:0004672 protein kinase activity
• GO:0004689 phosphorylase kinase activity
• GO:0005516 calmodulin binding
• GO:0005524 ATP binding

Biological Process

• GO:0005977 glycogen metabolic process
• GO:0006468 protein phosphorylation

Cellular Component

• GO:0005964 phosphorylase kinase complex

External links

• PDB: RCSB:1ql6, PDBe:1ql6, PDBj:1ql6
• PDBsum: 1ql6
• PubMed: 10545198
• UniProt: P00518|PHKG1_RABIT Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform (Gene Name=PHKG1)