Structure of PDB 1q9y Chain A Binding Site BS02

Receptor Information
>1q9y Chain A (length=902) Species: 12353 (Escherichia phage RB69) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HGSMKEFYLTVEQIGDSIFERYIDSNGRERTREVEYKPSLFAHCPESQAT
KYFDIYGKPCTRKLFANMRDASQWIKRMEDIGLEALGMDDFKLAYLSDTY
NYEIKYDHTKIRVANFDIEVTSPDGFPEPSQAKHPIDAITHYDSIDDRFY
VFDLLNSPYGNVEEWSIEIAAKLQEQGGDEVPSEIIDKIIYMPFDNEKEL
LMEYLNFWQQKTPVILTGWNVESFAIPYVYNRIKNIFGESTAKRLSPHRK
TRVKVIENMYGSREIITLFGISVLDYIDLYKKFSFTNQPSYSLDYISEFE
LNVGKLKYDGPISKLRESNHQRYISYNIIAVYRVLQIDAKRQFINLSLDM
GYYAKIQIQSVFSPIKTWDAIIFNSLKEQNKVIPQGRSHPVQPYPGAFVK
EPIPNRYKYVMSFDLTSLYPSIIRQVNISPETIAGTFKVAPLHDYINAVA
ERPSDVYSCSPNGMMYYKDRDGVVPTEITKVFNQRKEHKGYMLAAQRNGE
IIKEALHNPNLSVDEPLDVDYRFDFSDEIKEKIKKLSAKSLNEMLFRAQR
TEVAGMTAQINRKLLINSLYGALGNVWFRYYDLRNATAITTFGQMALQWI
ERKVNEYLNEVCGTEGEAFVLYGDTDSIYVSADKIIDKVGESKFRDTNHW
VDFLDKFARERMEPAIDRGFREMCEYMNNKQHLMFMDREAIAGPPLGSKG
IGGFWTGKKRYALNVWDMEGTRYAEPKLKIMGLETQKSSTPKAVQKALKE
CIRRMLQEGEESLQEYFKEFEKEFRQLNYISIASVSSANNIAKYDVGGFP
GPKCPFHIRGILTYNRAIKGNIDAPQVVEGEKVYVLPLREGNPFGDKCIA
WPSGTEITDLIKDDVLHWMDYTVLLEKTFIKPLEGFTSAAKLDYEKKASL
FD
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1q9y Lesion (in)tolerance reveals insights into DNA replication fidelity.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		N287 D624 T625 K709 M731 G732 K737 S738 S739 S786 S787 N789 Y794 K803 H807
Binding residue
(residue number reindexed from 1)		N287 D624 T625 K709 M731 G732 K737 S738 S739 S786 S787 N789 Y794 K803 H807
Binding affinityPDBbind-CN: Kd=20uM
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
3.1.11.-
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0004527 exonuclease activity
GO:0008408 3'-5' exonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0039686 bidirectional double-stranded viral DNA replication
GO:0039693 viral DNA genome replication

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1q9y, PDBe:1q9y, PDBj:1q9y
PDBsum1q9y
PubMed15057282
UniProtQ38087|DPOL_BPR69 DNA-directed DNA polymerase (Gene Name=43)

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