Structure of PDB 1q7l Chain A Binding Site BS02

Receptor Information
>1q7l Chain A (length=192) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EEEHPSVTLFRQYLRIRTVQPKPDYGAAVAFFEETARQLGLGCQKVEVAP
GYVVTVLTWPGTNPTLSSILLNSHTDVVPVFKEHWSHDPFEAFKDSEGYI
YARGAQDMKCVSIQYLEAVRRLKVEGHRFPRTIHMTFVPDEEVGGHQGME
LFVQRPEFHALRAGFALDEGIANPTDAFTVFYSERSPWWVRV
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain1q7l Chain A Residue 1001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB1q7l Essential roles of zinc ligation and enzyme dimerization for catalysis in the aminoacylase-1/M20 family.
Resolution1.4 Å
Binding residue
(original residue number in PDB)		D113 E148
Binding residue
(residue number reindexed from 1)		D107 E142
Annotation score1
Enzymatic activity
Enzyme Commision number 3.5.1.14: N-acyl-aliphatic-L-amino acid amidohydrolase.
Gene Ontology
Molecular Function
GO:0004046 aminoacylase activity
GO:0016787 hydrolase activity
Biological Process
GO:0006520 amino acid metabolic process
Cellular Component
GO:0005737 cytoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:1q7l, PDBe:1q7l, PDBj:1q7l
PDBsum1q7l
PubMed12933810
UniProtQ03154|ACY1_HUMAN Aminoacylase-1 (Gene Name=ACY1)

[Back to BioLiP]