Structure of PDB 1pv9 Chain A Binding Site BS02

Receptor Information
>1pv9 Chain A (length=337) Species: 2261 (Pyrococcus furiosus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LVKFMDENSIDRVFIAKPVNVYYFSGTSPLGGGYIIVDGDEATLYVPELE
YEMAKEESKLPVVKFKKFDEIYEILKNTETLGIEGTLSYSMVENFKEKSV
KEFKKIDDVIKDLRIIKTKEEIEIIEKACEIADKAVMAAIEEITEGKRER
EVAAKVEYLMKMNGAEKPAFDTIIASGHRSALPHGVASDKRIERGDLVVI
DLGALYNHYNSDITRTIVVGSPNEKQREIYEIVLEAQKRAVEAAKPGMTA
KELDSIAREIIKEYGYGDYFIHSLGHGVGLEIHEWPRISQYDETVLKEGM
VITIEPGIYIPKLGGVRIEDTVLITENGAKRLTKTER
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain1pv9 Chain A Residue 402 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1pv9 Structure of the Prolidase from Pyrococcus furiosus.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		D209 D220 E327
Binding residue
(residue number reindexed from 1)		D201 D212 E319
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) H192 D209 D220 T222 H280 H284 H291 E313 Y317 R325 E327
Catalytic site (residue number reindexed from 1) H184 D201 D212 T214 H272 H276 H283 E305 Y309 R317 E319
Enzyme Commision number 3.4.13.9: Xaa-Pro dipeptidase.
Gene Ontology
Molecular Function
GO:0008237 metallopeptidase activity
GO:0016805 dipeptidase activity
GO:0046872 metal ion binding
GO:0102009 proline dipeptidase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1pv9, PDBe:1pv9, PDBj:1pv9
PDBsum1pv9
PubMed15005612
UniProtP81535|PEPQ_PYRFU Xaa-Pro dipeptidase (Gene Name=pepQ)

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