Structure of PDB 1pm2 Chain A Binding Site BS02
Receptor Information
>1pm2 Chain A (length=339) Species:
562
(Escherichia coli) [
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AYTTFSQTKNDQLKEPMFFGQPVNVARYDQQKYDIFEKLIEKQLSFFWRP
EEVDVSRDRIDYQALPEHEKHIFISNLKYQTLLESIQGRSPNVALLPLIS
IPELETWVETWAFSETIHSRSYTHIIRNIVNDPSVVFDDIVTNEQIQKRA
EGISSYYDELIEMTSYWHLLGEGTHTVNGKTVTVSLRELKKKLYLCLMSV
NALEAIRFYVSFACSFAFAERELMEGNAKIIRLIARDEALHLTGTQHMLN
LLRSGADDPEMAEIAEECKQECYDLFVQAAQQEKDWADYLFRDGSMIGLN
KDILCQYVEYITNIRMQAVGLDLPFNTRSNPIPWINTWL
Ligand information
Ligand ID
MN
InChI
InChI=1S/Mn/q+2
InChIKey
WAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
Software
SMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0
[Mn+2]
CACTVS 3.341
[Mn++]
Formula
Mn
Name
MANGANESE (II) ION
ChEMBL
DrugBank
DB06757
ZINC
PDB chain
1pm2 Chain A Residue 502 [
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Receptor-Ligand Complex Structure
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PDB
1pm2
Variable coordination geometries at the diiron(II) active site of ribonucleotide reductase R2.
Resolution
1.8 Å
Binding residue
(original residue number in PDB)
W111 E115 E204 E238 H241
Binding residue
(residue number reindexed from 1)
W111 E115 E204 E238 H241
Annotation score
1
Enzymatic activity
Catalytic site (original residue number in PDB)
Y122 D237
Catalytic site (residue number reindexed from 1)
Y122 D237
Enzyme Commision number
1.17.4.1
: ribonucleoside-diphosphate reductase.
Gene Ontology
Molecular Function
GO:0004748
ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
GO:0005506
iron ion binding
GO:0005515
protein binding
GO:0016491
oxidoreductase activity
GO:0042802
identical protein binding
GO:0046872
metal ion binding
Biological Process
GO:0009185
ribonucleoside diphosphate metabolic process
GO:0009263
deoxyribonucleotide biosynthetic process
GO:0009265
2'-deoxyribonucleotide biosynthetic process
GO:0015949
nucleobase-containing small molecule interconversion
Cellular Component
GO:0005737
cytoplasm
GO:0005829
cytosol
GO:0005971
ribonucleoside-diphosphate reductase complex
View graph for
Molecular Function
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Biological Process
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Cellular Component
External links
PDB
RCSB:1pm2
,
PDBe:1pm2
,
PDBj:1pm2
PDBsum
1pm2
PubMed
14677973
UniProt
P69924
|RIR2_ECOLI Ribonucleoside-diphosphate reductase 1 subunit beta (Gene Name=nrdB)
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