Structure of PDB 1ph5 Chain A Binding Site BS02

Receptor Information

>1ph5 Chain A (length=459) Species: 200597 (Sterkiella nova)

YEYVELAKASLTSAQPQHFYAVVIDATFPYKTNQERYICSLKIVDPTLYL
KQQKGAGDASDYATLVLYAKRFEDLPIIHRAGDIIRVHRATLRLYNGQRQ
FNANVFYSSSWALFSTDKRSVTQEINNQDAVSDTTPFSFSSKHATIEKNE
ISILQNLRKWANQYFSSYSVISSDMYTALNKAQAQKGDFDVVAKILQVHE
LDEYTNELKLKDASGQVFYTLSLKLKFPHVRTGEVVRIRSATYDETSTQK
KVLILSHYSNIITFIQSSKLAKELRAKIQDDHSVEVASLKKNVSLNAVVL
TEVDKKHAALPSTSLQDLFHHADSDKELQAQDTFRTQFYVTKIEPSDVKE
WVKGYDRKTKKSSSLKGASGKGDNIFQVQFLVKDASTQLNNNTYRVLLYT
QDGLGANFFNVKADNLHKNADARKKLEDSAELLTKFNSYVDAVVERRNGF
YLIKDTKLI

Ligand information

>1ph5 Chain D (length=11)

gggttttgcgg

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1ph5 Nucleotide Shuffling and ssDNA Recognition in Oxytricha Nova Telomere End-Binding Protein Complexes
• Resolution: 2.3 Å
• Binding residue (original residue number in PDB): F63 Y65 K66 T67 Y72 S75 K77 F107 I112 Y130 Q135 D223 D225 Y239 L260 K261 R274 S275 H292 Y293
• Binding residue (residue number reindexed from 1): F28 Y30 K31 T32 Y37 S40 K42 F72 I77 Y95 Q100 D188 D190 Y204 L225 K226 R239 S240 H257 Y258

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0005515 protein binding
• GO:0010521 telomerase inhibitor activity
• GO:0043047 single-stranded telomeric DNA binding
• GO:0098505 G-rich strand telomeric DNA binding

Biological Process

• GO:0000723 telomere maintenance
• GO:0016233 telomere capping
• GO:0032210 regulation of telomere maintenance via telomerase

Cellular Component

• GO:0000781 chromosome, telomeric region
• GO:0000782 telomere cap complex
• GO:0000783 nuclear telomere cap complex
• GO:0005634 nucleus
• GO:0005694 chromosome
• GO:0032991 protein-containing complex

External links

• PDB: RCSB:1ph5, PDBe:1ph5, PDBj:1ph5
• PDBsum: 1ph5
• PubMed: 12912928
• UniProt: P29549|TEBA_STENO Telomere-binding protein subunit alpha (Gene Name=MAC-56A)