Structure of PDB 1ph1 Chain A Binding Site BS02

Receptor Information

>1ph1 Chain A (length=456) Species: 200597 (Sterkiella nova)

KYEYVELAKASLTSAQPQHFYAVVIDATFPYKTNQERYICSLKIVDPTLY
LKQDASDYATLVLYAKRFEDLPIIHRAGDIIRVHRATLRLYNGQRQFNAN
VFYSSSWALFSTDKRSVTQEINNQDAVSDTTPFSFSSKHATIEKNEISIL
QNLRKWANQYFSSYSVISSDMYTALNKAQAQKGDFDVVAKILQVHELDEY
TNELKLKDASGQVFYTLSLKLKFPHVRTGEVVRIRSATYDETSTQKKVLI
LSHYSNIITFIQSSKLAKELRAKIQDDHSVEVASLKKNVSLNAVVLTEVD
KKHAALPSTSLQDLFHHADSDKELQAQDTFRTQFYVTKIEPSDVKEWVKG
YDRKTKKSSSLKGASGKGDNIFQVQFLVKDASTQLNNNTYRVLLYTQDGL
GANFFNVKADNLHKNADARKKLEDSAELLTKFNSYVDAVVERRNGFYLIK
DTKLIY

Ligand information

>1ph1 Chain D (length=13)

ggggttttggggt

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1ph1 Nucleotide Shuffling and Ssdna Recognition in Oxytricha Nova Telomere End-Binding Protein Complexes
• Resolution: 2.51 Å
• Binding residue (original residue number in PDB): F63 Y65 K66 T67 N68 R71 Y72 I73 S75 K77 V101 Y103 F107 I112 Y130 Q135 D223 D225 Y239 L260 K261 R274 S275 H292 Y293
• Binding residue (residue number reindexed from 1): F29 Y31 K32 T33 N34 R37 Y38 I39 S41 K43 V62 Y64 F68 I73 Y91 Q96 D184 D186 Y200 L221 K222 R235 S236 H253 Y254

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0005515 protein binding
• GO:0010521 telomerase inhibitor activity
• GO:0043047 single-stranded telomeric DNA binding
• GO:0098505 G-rich strand telomeric DNA binding

Biological Process

• GO:0000723 telomere maintenance
• GO:0016233 telomere capping
• GO:0032210 regulation of telomere maintenance via telomerase

Cellular Component

• GO:0000781 chromosome, telomeric region
• GO:0000782 telomere cap complex
• GO:0000783 nuclear telomere cap complex
• GO:0005634 nucleus
• GO:0005694 chromosome
• GO:0032991 protein-containing complex

External links

• PDB: RCSB:1ph1, PDBe:1ph1, PDBj:1ph1
• PDBsum: 1ph1
• PubMed: 12912928
• UniProt: P29549|TEBA_STENO Telomere-binding protein subunit alpha (Gene Name=MAC-56A)