Structure of PDB 1oyo Chain A Binding Site BS02

Receptor Information
>1oyo Chain A (length=279) Species: 37998 (Parengyodontium album) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AAQTNAPWGLARISSTSPGTSTYYYDESAGQGSCVYVIDTGIEASHPEFE
GRAQMVKTYYYSSRDGNGHGTHCAGTVGSRTYGVAKKTQLFGVKVLDDNG
SGQYSTIIAGMDFVASDKNNRNCPKGVVASLSLGGGYSSSVNSAAARLQS
SGVMVAVAAGNNNADARNYSPASEPSVCTVGASDRYDRRSSFSNYGSVLD
IFGPGTSILSTWIGGSTRSISGTSMATPHVAGLAAYLMTLGKTTAASACR
YIADTANKGDLSNIPFGTVNLLAYNNYQA
Ligand information
Ligand ID3ID
InChIInChI=1S/C8H7NO2/c10-7-3-5-1-2-9-6(5)4-8(7)11/h1-4,9-11H
InChIKeySGNZYJXNUURYCH-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04Oc1cc2c(cc1O)ncc2
OpenEye OEToolkits 1.5.0c1c[nH]c2c1cc(c(c2)O)O
CACTVS 3.341Oc1cc2[nH]ccc2cc1O
FormulaC8 H7 N O2
Name3H-INDOLE-5,6-DIOL
ChEMBLCHEMBL92636
DrugBankDB01811
ZINCZINC000000895800
PDB chain1oyo Chain A Residue 694 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1oyo Regulation of protease activity by melanin: Crystal structure of the complex formed between proteinase K and melanin monomers at 2.0 resolution
Resolution2.02 Å
Binding residue
(original residue number in PDB)
H69 L96 S132 L133 G134 S224
Binding residue
(residue number reindexed from 1)
H69 L96 S132 L133 G134 S224
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) D39 H69 N161 S224
Catalytic site (residue number reindexed from 1) D39 H69 N161 S224
Enzyme Commision number 3.4.21.64: peptidase K.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function

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Biological Process
External links
PDB RCSB:1oyo, PDBe:1oyo, PDBj:1oyo
PDBsum1oyo
PubMed
UniProtP06873|PRTK_PARAQ Proteinase K (Gene Name=PROK)

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