Structure of PDB 1o0q Chain A Binding Site BS02

Receptor Information

>1o0q Chain A (length=453) Species: 76981 (Pseudomonas sp. 'TAC II 18')

GTSSAFTQIDNFSHFYDRGDHLVNGKPSFTVDQVADQLTRSGASWHDNDG
VINLTYTFLTAPPVGYASRGLGTFSQFSALQKEQAKLSLESWADVAKVTF
TEGPAARGDDGHMTFANFSASNGGAAFAYLPNSSRKGESWYLINKDYQVN
KTPGEGNYGRQTLTHEIGHTLGLSHPGDNPTYRDAVYAEDTRAYSVMSYW
SEKNTGQVFTKTGEGAYASAPLLDDIAAVQKLYGANLETRADDTVYGFNS
TADRDFYSATSSTDKLIFSVWDGGGNDTLDFSGFSQNQKINLTAGSFSDV
GGMTGNVSIAQGVTIENAIGGSGNDLLIGNDAANVLKGGAGNDIIYGGGG
ADVLWGGTGSDTFVFGAVSDSTPKAADIIKDFQSGFDKIDLTAITKLGGL
NFVDAFTGHAGDAIVSYHQASNAGSLQVDFSGQGVADFLVTTVGQVATYD
IVA

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 1o0q Chain A Residue 702

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1o0q Probing the role of divalent metal ions in a bacterial psychrophilic metalloprotease: binding studies of an enzyme in the crystalline state by x-ray crystallography.
• Resolution: 2.2 Å
• Binding residue (original residue number in PDB): G285 D287 T324 E326
• Binding residue (residue number reindexed from 1): G275 D277 T314 E316
• Annotation score: 4

Enzymatic activity

• Enzyme Commision number: 3.4.24.40: serralysin.

Gene Ontology

Molecular Function

• GO:0004222 metalloendopeptidase activity
• GO:0005509 calcium ion binding
• GO:0008237 metallopeptidase activity
• GO:0008270 zinc ion binding
• GO:0046872 metal ion binding

Biological Process

• GO:0006508 proteolysis

Cellular Component

• GO:0005615 extracellular space
• GO:0031012 extracellular matrix

External links

• PDB: RCSB:1o0q, PDBe:1o0q, PDBj:1o0q
• PDBsum: 1o0q
• PubMed: 12837794
• UniProt: O69771