Structure of PDB 1nzi Chain A Binding Site BS02

Receptor Information
>1nzi Chain A (length=155) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENC
AYDSVQIISEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEE
RFTGFAAYYVATDINECTDVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMK
NCGVN
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain1nzi Chain A Residue 1003 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1nzi X-ray structure of the Ca2+-binding interaction domain of C1s. Insights into the assembly of the C1 complex of complement
Resolution1.5 Å
Binding residue
(original residue number in PDB)		E45 D53 D98
Binding residue
(residue number reindexed from 1)		E45 D53 D95
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.21.42: complement subcomponent C1s.
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding

View graph for
Molecular Function
External links
PDB RCSB:1nzi, PDBe:1nzi, PDBj:1nzi
PDBsum1nzi
PubMed12788922
UniProtP09871|C1S_HUMAN Complement C1s subcomponent (Gene Name=C1S)

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