Structure of PDB 1npg Chain A Binding Site BS02

Receptor Information

>1npg Chain A (length=152) Species: 9796 (Equus caballus)

GLSDGEWQQVLNVWGKVEADIAGHGQEVLIRLFTGHPETLEKFDKFKHLK
TEAEMKASEDLKKHGTVVLTALGGILKKKGHHEAELKPLAQSHATKHKIP
IKYLEFISDAIIHVLHSKHPGDFGADAQGAMTKALELFRNDIAAKYKELG
FQ

Ligand information

• Ligand ID: NOE
• InChI: InChI=1S/C2H5NO/c1-2-3-4/h2H2,1H3
• InChIKey: IFYCAQIXDKZDTB-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04: O=NCC
  CACTVS 3.341
  OpenEye OEToolkits 1.5.0: CCN=O
• Formula: C2 H5 N O
• Name: NITROSOETHANE
• DrugBank: DB02646
• PDB chain: 1npg Chain A Residue 155

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1npg Crystal structures of ferrous horse heart myoglobin complexed with nitric oxide and nitrosoethane.
• Resolution: 1.7 Å
• Binding residue (original residue number in PDB): F43 H64 V68 I107
• Binding residue (residue number reindexed from 1): F43 H64 V68 I107
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 1.11.1.-
  1.7.-.-

Gene Ontology

Molecular Function

• GO:0004601 peroxidase activity
• GO:0005344 oxygen carrier activity
• GO:0016491 oxidoreductase activity
• GO:0019825 oxygen binding
• GO:0020037 heme binding
• GO:0046872 metal ion binding
• GO:0098809 nitrite reductase activity

Biological Process

• GO:0015671 oxygen transport
• GO:0019430 removal of superoxide radicals

Cellular Component

• GO:0005737 cytoplasm
• GO:0016528 sarcoplasm

External links

• PDB: RCSB:1npg, PDBe:1npg, PDBj:1npg
• PDBsum: 1npg
• PubMed: 14517970
• UniProt: P68082|MYG_HORSE Myoglobin (Gene Name=MB)