Structure of PDB 1nos Chain A Binding Site BS02

Receptor Information

>1nos Chain A (length=323) Species: 10090 (Mus musculus)

NPKSLTRGPRDKPTPLEELLPHAIEFINQYYGSFKEAKIEEHLARLEAVT
KEIETTGTYQLTLDELIFATKMAWRNAPRCIGRIQWSNLQVFDARNCSTA
QEMFQHICRHILYATNNGNIRSAITVFPQRSDGKHDFRLWNSQLIRYAGY
QMPDGTIRGDAATLEFTQLCIDLGWKPRYGRFDVLPLVLQADGQDPEVFE
IPPDLVLEVTMELGLKWYALPAVANMLLEVGGLEFPACPFNGWYMGTEIG
VRDFCDTQDRAVTEINVAVLHSFQKQNVTIMDHHTASESFMKHMQNEYVL
SPFYYYQIEPWKTHIWQNEHHHH

Ligand information

• Ligand ID: IMD
• InChI: InChI=1S/C3H4N2/c1-2-5-3-4-1/h1-3H,(H,4,5)/p+1
• InChIKey: RAXXELZNTBOGNW-UHFFFAOYSA-O
• SMILES:
  CACTVS 3.341: [nH]1cc[nH+]c1
  ACDLabs 10.04: c1c[nH+]cn1
  OpenEye OEToolkits 1.5.0: c1c[nH+]c[nH]1
• Formula: C3 H5 N2
• Name: IMIDAZOLE
• PDB chain: 1nos Chain A Residue 903

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1nos The structure of nitric oxide synthase oxygenase domain and inhibitor complexes.
• Resolution: 2.1 Å
• Binding residue (original residue number in PDB): Y367 E371
• Binding residue (residue number reindexed from 1): Y244 E248
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): C194 R197 W366 E371
• Catalytic site (residue number reindexed from 1): C80 R83 W243 E248
• Enzyme Commision number: 1.14.13.39: nitric-oxide synthase (NADPH).

Gene Ontology

Molecular Function

• GO:0004517 nitric-oxide synthase activity
• GO:0020037 heme binding

Biological Process

• GO:0006809 nitric oxide biosynthetic process

External links

• PDB: RCSB:1nos, PDBe:1nos, PDBj:1nos
• PDBsum: 1nos
• PubMed: 9334294
• UniProt: P29477|NOS2_MOUSE Nitric oxide synthase, inducible (Gene Name=Nos2)