Structure of PDB 1nh3 Chain A Binding Site BS02

Receptor Information
>1nh3 Chain A (length=471) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
WKWWEEERYPEGIKWKFLEHKGPVFAPPYEPLPENVKFYYDGKVMKLSPK
AEEVATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNEEKNIITNLSKCDF
TQMSQYFKAQTEARKQMSKEEKLKIKEENEKLLKEYGFCIMDNHKERIAN
FKIEPPGLFRGRGNHPKMGMLKRRIMPEDIIINCSKDAKVPSPPPGHKWK
EVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYETARRLKK
CVDKIRNQYREDWKSKEMKVRQRAVALYFIDKLALRAGNEKEEGETADTV
GCCSLRVEHINLHPELDGQEYVVEFDFLGKDSIRYYNKVPVEKRVFKNLQ
LFMENKQPEDDLFDRLNTGILNKHLQDLMEGLTAKVFRTYNASITLQQQL
KELTAPDENIPAKILSYNRANRAVSKLNYLDPRITVAWCKKWGVPIEKIY
NKTQREKFAWAIDMADEDYEF
Ligand information
Receptor-Ligand Complex Structure
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PDB1nh3 Structural Impact of the Leukemia Drug 1-beta-D-Arabinofuranosylcytosine (Ara-C) on the Covalent Human Topoisomerase I-DNA Complex
Resolution3.1 Å
Binding residue
(original residue number in PDB)		H266 R364 N722 Y723
Binding residue
(residue number reindexed from 1)		H64 R162 N428 Y429
Enzymatic activity
Enzyme Commision number 5.6.2.1: DNA topoisomerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003917 DNA topoisomerase type I (single strand cut, ATP-independent) activity
Biological Process
GO:0006265 DNA topological change
Cellular Component
GO:0005694 chromosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1nh3, PDBe:1nh3, PDBj:1nh3
PDBsum1nh3
PubMed12533542
UniProtP11387|TOP1_HUMAN DNA topoisomerase 1 (Gene Name=TOP1)

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