Structure of PDB 1mpo Chain A Binding Site BS02

Receptor Information
>1mpo Chain A (length=421) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VDFHGYARSGIGWTGSGGEQQCFQTTGAQSKYRLGNECETYAELKLGQEV
WKEGDKSFYFDTNVAYSVAQQNDWEATDPAFREANVQGKNLIEWLPGSTI
WAGKRFYQRHDVHMIDFYYWDISGPGAGLENIDVGFGKLSLAATRSSEAG
GSSSFASNNIYDYTNETANDVFDVRLAQMEINPGGTLELGVDYGRANLRD
NYRLVDGASKDGWLFTAEHTQSVLKGFNKFVVQYATDSMTSQGKGLSQGS
GVAFDNEKFAYNINNNGHMLRILDHGAISMGDNWDMMYVGMYQDINWDND
NGTKWWTVGIRPMYKWTPIMSTVMEIGYDNVESQRTGDKNNQYKITLAQQ
WQAGDSIWSRPAIRVFATYAKWDEKWGYDYTGNADNNANFGKAVPADFNG
GSFGRGDSDEWTFGAQMEIWW
Ligand information
Ligand IDGLC
InChIInChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6+/m1/s1
InChIKeyWQZGKKKJIJFFOK-DVKNGEFBSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(C1C(C(C(C(O1)O)O)O)O)O
OpenEye OEToolkits 1.5.0C([C@@H]1[C@H]([C@@H]([C@H]([C@H](O1)O)O)O)O)O
CACTVS 3.341OC[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
CACTVS 3.341OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O
ACDLabs 10.04OC1C(O)C(OC(O)C1O)CO
FormulaC6 H12 O6
Namealpha-D-glucopyranose;
alpha-D-glucose;
D-glucose;
glucose
ChEMBLCHEMBL423707
DrugBank
ZINCZINC000003861213
PDB chain1mpo Chain D Residue 2 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1mpo Crystal structures of various maltooligosaccharides bound to maltoporin reveal a specific sugar translocation pathway.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		Y6 R8 R33 Y41 E43 D116 Y118
Binding residue
(residue number reindexed from 1)		Y6 R8 R33 Y41 E43 D116 Y118
Annotation score3
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0001618 virus receptor activity
GO:0005363 maltose transmembrane transporter activity
GO:0005515 protein binding
GO:0015144 carbohydrate transmembrane transporter activity
GO:0015288 porin activity
GO:0042958 maltodextrin transmembrane transporter activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0006974 DNA damage response
GO:0015768 maltose transport
GO:0015774 polysaccharide transport
GO:0034219 carbohydrate transmembrane transport
GO:0042956 maltodextrin transmembrane transport
GO:0046718 symbiont entry into host cell
GO:1904981 maltose transmembrane transport
Cellular Component
GO:0009279 cell outer membrane
GO:0016020 membrane
GO:0046930 pore complex
GO:0106234 outer membrane protein complex

View graph for
Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:1mpo, PDBe:1mpo, PDBj:1mpo
PDBsum1mpo
PubMed8805519
UniProtP02943|LAMB_ECOLI Maltoporin (Gene Name=lamB)

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