Structure of PDB 1mdx Chain A Binding Site BS02

Receptor Information
>1mdx Chain A (length=366) Species: 90371 (Salmonella enterica subsp. enterica serovar Typhimurium) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DFLPFSRPAMGAEELAAVKTVLDSGWITTGPKNQELEAAFCRLTGNQYAV
AVSSATAGMHIALMALGIGEGDEVITPSMTWVSTLNMIVLLGANPVMVDV
DRDTLMVTPEHIEAAITPQTKAIIPVHYAGAPADLDAIYALGERYGIPVI
EDAAHATGTSYKGRHIGARGTAIFSFHAIKNITCAEGGIVVTDNPQFADK
LRSLKFHGLGRAPQAEVLAPGYKYNLPDLNAAIALAQLQKLDALNARRAA
IAAQYHQAMADLPFQPLSLPSWEHIHAWHLFIIRVDEARCGITRDALMAS
LKTKGIGTGLHFRAAHTQKYYRERFPTLTLPDTEWNSERICSLPLFPDMT
ESDFDRVITALHQIAG
Ligand information
Ligand IDAKG
InChIInChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)
InChIKeyKPGXRSRHYNQIFN-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04O=C(O)C(=O)CCC(=O)O
OpenEye OEToolkits 1.7.6C(CC(=O)O)C(=O)C(=O)O
CACTVS 3.385OC(=O)CCC(=O)C(O)=O
FormulaC5 H6 O5
Name2-OXOGLUTARIC ACID
ChEMBLCHEMBL1686
DrugBankDB08845
ZINCZINC000001532519
PDB chain1mdx Chain A Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1mdx Structural studies of Salmonella typhimurium ArnB (PmrH) aminotransferase: A 4-amino-4-deoxy-L-arabinose lipopolysaccharide modifying enzyme
Resolution1.96 Å
Binding residue
(original residue number in PDB)		H185 E194
Binding residue
(residue number reindexed from 1)		H177 E186
Annotation score5
Enzymatic activity
Enzyme Commision number 2.6.1.87: UDP-4-amino-4-deoxy-L-arabinose aminotransferase.
Gene Ontology
Molecular Function
GO:0008483 transaminase activity
GO:0030170 pyridoxal phosphate binding
GO:0099620 UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Biological Process
GO:0000271 polysaccharide biosynthetic process
GO:0009103 lipopolysaccharide biosynthetic process
GO:0009245 lipid A biosynthetic process
GO:0046493 lipid A metabolic process
GO:0046677 response to antibiotic

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Molecular Function
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Biological Process
External links
PDB RCSB:1mdx, PDBe:1mdx, PDBj:1mdx
PDBsum1mdx
PubMed12429098
UniProtQ8ZNF3|ARNB_SALTY UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase (Gene Name=arnB)

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