Structure of PDB 1m32 Chain A Binding Site BS02

Receptor Information
>1m32 Chain A (length=361) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
YLLLTPGPLTTSRTVKEAMLFDSCTWDDDYNIGVVEQIRQQLTALATASE
GYTSVLLQGSGSYAVEAVLGSALGPQDKVLIVSNGAYGARMVEMAGLMGI
AHHAYDCGEVARPDVQAIDAILNADPTISHIAMVHSETTTGMLNPIDEVG
ALAHRYGKTYIVDAMSSFGGIPMDIAALHIDYLISSANKCIQGVPGFAFV
IAREQKLAACKGHSRSLSLDLYAQWRCMEDNHGKWRFTSPTHTVLAFAQA
LKELAKEGGVAARHQRYQQNQRSLVAGMRALGFNTLLDDELHSPIITAFY
SPEDPQYRFSEFYRRLKEQGFVIYPGKVSQSDCFRIGNIGEVYAADITAL
LTAIRTAMYWT
Ligand information
Ligand IDPOA
InChIInChI=1S/C2H5O4P/c3-1-2-7(4,5)6/h1H,2H2,(H2,4,5,6)
InChIKeyYEMKIGUKNDOZEG-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341O[P](O)(=O)CC=O
OpenEye OEToolkits 1.5.0C(C=O)P(=O)(O)O
ACDLabs 10.04O=CCP(=O)(O)O
FormulaC2 H5 O4 P
NamePHOSPHONOACETALDEHYDE
ChEMBL
DrugBankDB03174
ZINC
PDB chain1m32 Chain A Residue 4601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1m32 Degradation Pathway of the Phosphonate Ciliatine: Crystal Structure of 2-Aminoethylphosphonate Transaminase
Resolution2.2 Å
Binding residue
(original residue number in PDB)		Y91 Y328 R339
Binding residue
(residue number reindexed from 1)		Y87 Y324 R335
Annotation score5
Enzymatic activity
Enzyme Commision number 2.6.1.37: 2-aminoethylphosphonate--pyruvate transaminase.
Gene Ontology
Molecular Function
GO:0008483 transaminase activity
GO:0047304 2-aminoethylphosphonate-pyruvate transaminase activity
Biological Process
GO:0019700 organic phosphonate catabolic process

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:1m32, PDBe:1m32, PDBj:1m32
PDBsum1m32
PubMed12403617
UniProtP96060|PHNW_SALTY 2-aminoethylphosphonate--pyruvate transaminase (Gene Name=phnW)

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