Structure of PDB 1lpq Chain A Binding Site BS02

Receptor Information
>1lpq Chain A (length=557) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KWKWWEEERYPEGIKWKFLEHKGPVFAPPYEPLPENVKFYYDGKVMKLSP
KAEEVATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNEEKNIITNLSKCD
FTQMSQYFKAQTEARKQMSKEEKLKIKEENEKLLKEYGFCIMDNHKERIA
NFKIEPPGLFRGRGNHPKMGMLKRRIMPEDIIINCSKDAKVPSPPPGHKW
KEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYETARRLK
KCVDKIRNQYREDWKSKEMKVRQRAVALYFIDKLALRAGNEKEEGETADT
VGCCSLRVEHINLHPELDGQEYVVEFDFLGKDSIRYYNKVPVEKRVFKNL
QLFMENKQPEDDLFDRLNTGILNKHLQDLMEGLTAKVFRTYNASITLQQQ
LKELTAPDENIPAKILSYNRANRAVAILCNHQEKSMMNLQTKIDAKKEQL
ADARRDLKSAKADAKVMKDAKTKKVVESKKKAVQRLEEQLMKLEVQATDR
EENKQIALGTSKLNFLDPRITVAWCKKWGVPIEKIYNKTQREKFAWAIDM
ADEDYEF
Ligand information
Receptor-Ligand Complex Structure
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PDB1lpq 8-Oxoguanine rearranges the active site of human topoisomerase I
Resolution3.14 Å
Binding residue
(original residue number in PDB)		E356 G363 H367 K425 R488 G490 N491 K493 T501 K532 D533 Q578 T585 A586 K587 N745 K746 T747
Binding residue
(residue number reindexed from 1)		E155 G162 H166 K224 R287 G289 N290 K292 T300 K331 D332 Q377 T384 A385 K386 N537 K538 T539
Enzymatic activity
Enzyme Commision number 5.6.2.1: DNA topoisomerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003917 DNA topoisomerase type I (single strand cut, ATP-independent) activity
Biological Process
GO:0006265 DNA topological change
Cellular Component
GO:0005694 chromosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1lpq, PDBe:1lpq, PDBj:1lpq
PDBsum1lpq
PubMed12209008
UniProtP11387|TOP1_HUMAN DNA topoisomerase 1 (Gene Name=TOP1)

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