Structure of PDB 1lc5 Chain A Binding Site BS02

Receptor Information
>1lc5 Chain A (length=355) Species: 28901 (Salmonella enterica) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LFNTAHGGNIREPATVLGISPDQLLDFSANINPLGMPVSVKRALIDNLDC
IERYPDADYFHLHQALARHHQVPASWILAGNGETESIFTVASGLKPRRAM
IVTPGFAEYGRALAQSGCEIRRWSLREADGWQLTDAILEALTPDLDCLFL
CTPNNPTGLLPERPLLQAIADRCKSLNINLILDEAFIDFIPHETGFIPAL
KDNPHIWVLRSLTKFYAIPGLRLGYLVNSDDAAMARMRRQQMPWSVNALA
ALAGEVALQDSAWQQATWHWLREEGARFYQALCQLPLLTVYPGRANYLLL
RCEREDIDLQRRLLTQRILIRSCANYPGLDSRYYRVAIRSAAQNERLLAA
LRNVL
Ligand information
Ligand IDPO4
InChIInChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3
InChIKeyNBIIXXVUZAFLBC-UHFFFAOYSA-K
SMILES
SoftwareSMILES
CACTVS 3.341[O-][P]([O-])([O-])=O
ACDLabs 10.04[O-]P([O-])([O-])=O
OpenEye OEToolkits 1.5.0[O-]P(=O)([O-])[O-]
FormulaO4 P
NamePHOSPHATE ION
ChEMBL
DrugBankDB14523
ZINC
PDB chain1lc5 Chain A Residue 800 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB1lc5 Structural studies of the L-threonine-O-3-phosphate decarboxylase (CobD) enzyme from Salmonella enterica: the apo, substrate, and product-aldimine complexes.
Resolution1.46 Å
Binding residue
(original residue number in PDB)		G84 E85 T86 S213 T215 K216 R224
Binding residue
(residue number reindexed from 1)		G82 E83 T84 S211 T213 K214 R222
Annotation score1
Enzymatic activity
Enzyme Commision number 4.1.1.81: threonine-phosphate decarboxylase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0016829 lyase activity
GO:0030170 pyridoxal phosphate binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0048472 threonine-phosphate decarboxylase activity
Biological Process
GO:0009058 biosynthetic process
GO:0009236 cobalamin biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1lc5, PDBe:1lc5, PDBj:1lc5
PDBsum1lc5
PubMed12119022
UniProtP97084|COBD_SALTY Threonine-phosphate decarboxylase (Gene Name=cobD)

[Back to BioLiP]