Structure of PDB 1k23 Chain A Binding Site BS02

Receptor Information

>1k23 Chain A (length=307) Species: 1423 (Bacillus subtilis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

MEKILIFGHQNPDTDTICSAIAYADLKNKLGFNAEPVRLGQVNGETQYAL
DYFKQESPRLVETAANEVNGVILVDHNERQQSIKDIEEVQVLEVIDHHRI
ANFETAEPLYYRAEPVGCTATILNKMYKENNVKIEKEIAGLMLSAIISDS
LLFKSPTCTDQDVAAAKELAEIAGVDAEEYGLNMLKAGADLSKKTVEELI
SLDAKEFTLGSKKVEIAQVNTVDIEDVKKRQAELEAVISKVVAEKNLDLF
LLVITDILENDSLALAIGNEAAKVEKAFNVTLENNTALLKGVVSRKKQVV
PVLTDAM

Ligand information

Ligand ID

InChI

InChI=1S/Mn/q+2

InChIKey

WAEMQWOKJMHJLA-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Mn+2]
CACTVS 3.341	[Mn++]

Formula

Name

MANGANESE (II) ION

PDB chain

1k23 Chain A Residue 402 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	1k23 The "open" and "closed" structures of the type-C inorganic pyrophosphatases from Bacillus subtilis and Streptococcus gordonii.
Resolution	3.0 Å
Binding residue (original residue number in PDB)	D15 D75 H97 T119 D149
Binding residue (residue number reindexed from 1)	D15 D75 H97 T119 D149
Annotation score	1

Enzymatic activity

Enzyme Commision number

3.6.1.1: inorganic diphosphatase.

Gene Ontology

	Molecular Function
GO:0004427	inorganic diphosphate phosphatase activity
GO:0016462	pyrophosphatase activity
GO:0016787	hydrolase activity
GO:0030145	manganese ion binding
GO:0046872	metal ion binding

	Cellular Component
GO:0005737	cytoplasm

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Molecular Function

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Cellular Component

External links

PDB	RCSB:1k23, PDBe:1k23, PDBj:1k23
PDBsum	1k23
PubMed	11697905
UniProt	P37487\|PPAC_BACSU Manganese-dependent inorganic pyrophosphatase (Gene Name=ppaC)

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