Structure of PDB 1jfk Chain A Binding Site BS02

Receptor Information
>1jfk Chain A (length=134) Species: 5759 (Entamoeba histolytica) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MAEALFKEIDVNGDGAVSYEEVKAFVSKKRAIKNEQLLQLIFKSIDADGN
GEIDQNEFAKFYGSIQGQDLSDDKIGLKVLYKLMDVDGDGKLTKEEVTSF
FKKHGIEKVAEQVMKADANGDGYITLEEFLEFSL
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain1jfk Chain A Residue 159 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1jfk NMR derived solution structure of an EF-hand calcium-binding protein from Entamoeba Histolytica.
ResolutionN/A
Binding residue
(original residue number in PDB)		D46 D48 N50 E52 I53 E57
Binding residue
(residue number reindexed from 1)		D46 D48 N50 E52 I53 E57
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003779 actin binding
GO:0003785 actin monomer binding
GO:0005509 calcium ion binding
GO:0046872 metal ion binding
GO:0051015 actin filament binding
Biological Process
GO:0006909 phagocytosis
GO:0032231 regulation of actin filament bundle assembly
GO:0045859 regulation of protein kinase activity
GO:0050766 positive regulation of phagocytosis
GO:1905303 positive regulation of macropinocytosis
Cellular Component
GO:0001891 phagocytic cup
GO:0005737 cytoplasm
GO:0031143 pseudopodium
GO:0042995 cell projection

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1jfk, PDBe:1jfk, PDBj:1jfk
PDBsum1jfk
PubMed11724551
UniProtP38505|CABP1_ENTH1 Calcium-binding protein 1 (Gene Name=CaBP1)

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