Structure of PDB 1j8r Chain A Binding Site BS02

Receptor Information

>1j8r Chain A (length=196) Species: 562 (Escherichia coli)

WNNIVFYSLGDVNSYQGGNVVITQRPQFITSWRPGIATVTWNQCNGPEFA
DGFWAYYREYIAWVVFPKKVMTQNGYPLFIEVHNKGSWSEENTGDNDSYF
FLKGYKWDERAFDAGNLCQKPGEITRLTEKFDDIIFKVALPADLPLGDYS
VKIPYTSGMQRHFASYLGARFKIPYNVAKTLPRENEMLFLFKNIGG

Ligand information

• Ligand ID: GLA
• InChI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3+,4+,5-,6+/m1/s1
• InChIKey: WQZGKKKJIJFFOK-PHYPRBDBSA-N
• SMILES:
  CACTVS 3.341: OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O
  OpenEye OEToolkits 1.5.0: C(C1C(C(C(C(O1)O)O)O)O)O
  OpenEye OEToolkits 1.5.0: C([C@@H]1[C@@H]([C@@H]([C@H]([C@H](O1)O)O)O)O)O
  CACTVS 3.341: OC[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
  ACDLabs 10.04: OC1C(O)C(OC(O)C1O)CO
• Formula: C6 H12 O6
• Name: alpha-D-galactopyranose;
  alpha-D-galactose;
  D-galactose;
  galactose;
  ALPHA D-GALACTOSE
• ChEMBL: CHEMBL1233058
• ZINC: ZINC000000901155
• PDB chain: 1j8r Chain B Residue 3

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1j8r Structural basis of the interaction of the pyelonephritic E. coli adhesin to its human kidney receptor.
• Resolution: 1.8 Å
• Binding residue (original residue number in PDB): E91 K103 G104 K172
• Binding residue (residue number reindexed from 1): E91 K103 G104 K172
• Annotation score: 4

Gene Ontology

Molecular Function

• GO:0030246 carbohydrate binding

Biological Process

• GO:0007155 cell adhesion

External links

• PDB: RCSB:1j8r, PDBe:1j8r, PDBj:1j8r
• PDBsum: 1j8r
• PubMed: 11440716
• UniProt: Q47450|PAPG2_ECOLX Fimbrial adhesin PapGII (Gene Name=papGII)