Structure of PDB 1iik Chain A Binding Site BS02

Receptor Information
>1iik Chain A (length=116) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
CPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLT
TEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAA
LLSPCSYSTTAVVTNP
Ligand information
Ligand IDBME
InChIInChI=1S/C2H6OS/c3-1-2-4/h3-4H,1-2H2
InChIKeyDGVVWUTYPXICAM-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(CS)O
ACDLabs 10.04
CACTVS 3.341		OCCS
FormulaC2 H6 O S
NameBETA-MERCAPTOETHANOL
ChEMBLCHEMBL254951
DrugBankDB03345
ZINCZINC000008216595
PDB chain1iik Chain A Residue 903 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1iik Disulfide-Bond Formation in the Transthyretin Mutant Y114C Prevents Amyloid Fibril Formation in Vivo and in Vitro
Resolution2.0 Å
Binding residue
(original residue number in PDB)		A108 S117 T118 T119
Binding residue
(residue number reindexed from 1)		A99 S108 T109 T110
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005179 hormone activity
GO:0005515 protein binding
GO:0042802 identical protein binding
GO:0070324 thyroid hormone binding
Biological Process
GO:0006144 purine nucleobase metabolic process
GO:0007165 signal transduction
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0035578 azurophil granule lumen
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1iik, PDBe:1iik, PDBj:1iik
PDBsum1iik
PubMed12403615
UniProtP02766|TTHY_HUMAN Transthyretin (Gene Name=TTR)

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