Structure of PDB 1ic8 Chain A Binding Site BS02
Receptor Information
>1ic8 Chain A (length=170) Species:
9606
(Homo sapiens) [
Search protein sequence
] [
Download receptor structure
] [
Download structure with residue number starting from 1
] [
View receptor structure
]
KELENLSPEEAAHQKAVVETLLQEDPWRVAKMVKSYLQQHNIPQREVVDT
TGLNQSHLSQHLNKGTPMKTQKRAALYTWYVRKQREVAQQFTHARNRFKW
GPASQQILFQAYERQKNPSKEERETLVEECNRAECIQRGVSPSQAQGLGS
NLVTEVRVYNWFANRRKEEA
Ligand information
>1ic8 Chain F (length=21) [
Search DNA sequence
] [
Download ligand structure
] [
Download structure with residue number starting from 1
] [
View ligand structure
]
tctggtgaattattaaccaag
Receptor-Ligand Complex Structure
Global view
Local view
Structure summary
[
Spin on
] [
Spin off
] [
Reset
]
[
High quality
] [
Low quality
]
[
White background
] [
Black background
]
[
Spin on
] [
Spin off
] [
Reset
]
[
High quality
] [
Low quality
]
[
White background
] [
Black background
]
PDB
1ic8
Diabetes mutations delineate an atypical POU domains in HNF1-Alpha
Resolution
2.6 Å
Binding residue
(original residue number in PDB)
N140 S142 H143 P153 M154 K155 K158 F204 K205 W206 R263 N270
Binding residue
(residue number reindexed from 1)
N54 S56 H57 P67 M68 K69 K72 F98 K99 W100 R157 N164
Enzymatic activity
Enzyme Commision number
?
Gene Ontology
Molecular Function
GO:0003677
DNA binding
Biological Process
GO:0001889
liver development
GO:0006357
regulation of transcription by RNA polymerase II
GO:0030073
insulin secretion
GO:0031016
pancreas development
GO:0045893
positive regulation of DNA-templated transcription
Cellular Component
GO:0005634
nucleus
View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB
RCSB:1ic8
,
PDBe:1ic8
,
PDBj:1ic8
PDBsum
1ic8
PubMed
12453420
UniProt
P20823
|HNF1A_HUMAN Hepatocyte nuclear factor 1-alpha (Gene Name=HNF1A)
[
Back to BioLiP
]