Structure of PDB 1hyi Chain A Binding Site BS02

Receptor Information
>1hyi Chain A (length=65) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RKWAEDNEVQNCMACGKGFSVTVRRHHCRQCGNIFCAECSAKNALTPSSK
KPVRVCDACFNDLQG
Ligand information
Ligand IDITP
InChIInChI=1S/C6H14O12P2/c7-1-2(8)5(17-19(11,12)13)4(10)6(3(1)9)18-20(14,15)16/h1-10H,(H2,11,12,13)(H2,14,15,16)/t1-,2-,3+,4+,5+,6-
InChIKeyPUVHMWJJTITUGO-FICORBCRSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C1([C@@H]([C@H](C([C@H]([C@@H]1O)OP(=O)(O)O)O)OP(=O)(O)O)O)O
CACTVS 3.341O[CH]1[CH](O)[CH](O[P](O)(O)=O)[CH](O)[CH](O[P](O)(O)=O)[CH]1O
ACDLabs 10.04O=P(OC1C(O)C(O)C(O)C(OP(=O)(O)O)C1O)(O)O
OpenEye OEToolkits 1.5.0C1(C(C(C(C(C1O)OP(=O)(O)O)O)OP(=O)(O)O)O)O
CACTVS 3.341O[C@H]1[C@H](O)[C@@H](O[P](O)(O)=O)[C@@H](O)[C@@H](O[P](O)(O)=O)[C@@H]1O
FormulaC6 H14 O12 P2
NamePHOSPHORIC ACID MONO-(2,3,4,6-TETRAHYDROXY-5-PHOSPHONOOXY-CYCLOHEXYL) ESTER;
INOSITOL 1,3-BISPHOSPHATE
ChEMBL
DrugBankDB02942
ZINCZINC000100016181
PDB chain1hyi Chain A Residue 68 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1hyi Structural mechanism of endosome docking by the FYVE domain.
ResolutionN/A
Binding residue
(original residue number in PDB)		R25 H26 H27 R29
Binding residue
(residue number reindexed from 1)		R25 H26 H27 R29
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:1hyi, PDBe:1hyi, PDBj:1hyi
PDBsum1hyi
PubMed11230696
UniProtQ15075|EEA1_HUMAN Early endosome antigen 1 (Gene Name=EEA1)

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