Structure of PDB 1htn Chain A Binding Site BS02

Receptor Information

>1htn Chain A (length=156) Species: 9606 (Homo sapiens)

LKSRLDTLSQEVALLKEQQALQTVCLKGTKVHMKCFLAFTQTKTFHEASE
DCISRGGTLSTPQTGSENDALYEYLRQSVGNEAEIWLGLNDMAAEGTWVD
MTGARIAYKNWETEITAQPDGGKTENCAVLSGAANGKWFDKRCRDQLPYI
CQFGIV

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 1htn Chain A Residue 183

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1htn Crystal structure of tetranectin, a trimeric plasminogen-binding protein with an alpha-helical coiled coil.
• Resolution: 2.8 Å
• Binding residue (original residue number in PDB): Q143 D145 E150 D165
• Binding residue (residue number reindexed from 1): Q118 D120 E125 D140
• Annotation score: 4

Gene Ontology

Molecular Function

• GO:0005509 calcium ion binding
• GO:0008201 heparin binding
• GO:0030246 carbohydrate binding
• GO:0036143 kringle domain binding

Biological Process

• GO:0001503 ossification
• GO:0010756 positive regulation of plasminogen activation
• GO:0030282 bone mineralization

Cellular Component

• GO:0001652 granular component
• GO:0005576 extracellular region
• GO:0005615 extracellular space
• GO:0005737 cytoplasm
• GO:0031089 platelet dense granule lumen
• GO:0062023 collagen-containing extracellular matrix
• GO:0070062 extracellular exosome

External links

• PDB: RCSB:1htn, PDBe:1htn, PDBj:1htn
• PDBsum: 1htn
• PubMed: 9256258
• UniProt: P05452|TETN_HUMAN Tetranectin (Gene Name=CLEC3B)