Structure of PDB 1hlc Chain A Binding Site BS02
Receptor Information
>1hlc Chain A (length=129) Species:
9606
(Homo sapiens) [
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ELEVKNMDMKPGSTLKITGSIADGTDGFVINLGQGTDKLNLHFNPRFSES
TIVCNSLDGSNWGQEQREDHLCFSPGSEVKFTVTFESDKFKVKLPDGHEL
TFPNRLGHSHLSYLSVRGGFNMSSFKLKE
Ligand information
Ligand ID
GAL
InChI
InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3+,4+,5-,6-/m1/s1
InChIKey
WQZGKKKJIJFFOK-FPRJBGLDSA-N
SMILES
Software
SMILES
CACTVS 3.370
OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@H]1O
OpenEye OEToolkits 1.7.2
C(C1C(C(C(C(O1)O)O)O)O)O
CACTVS 3.370
OC[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
ACDLabs 12.01
OC1C(O)C(OC(O)C1O)CO
OpenEye OEToolkits 1.7.2
C([C@@H]1[C@@H]([C@@H]([C@H]([C@@H](O1)O)O)O)O)O
Formula
C6 H12 O6
Name
beta-D-galactopyranose;
beta-D-galactose;
D-galactose;
galactose
ChEMBL
CHEMBL300520
DrugBank
ZINC
ZINC000002597049
PDB chain
1hlc Chain C Residue 2 [
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Receptor-Ligand Complex Structure
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PDB
1hlc
X-ray crystal structure of the human dimeric S-Lac lectin, L-14-II, in complex with lactose at 2.9-A resolution.
Resolution
2.9 Å
Binding residue
(original residue number in PDB)
H45 N58 W65 E68
Binding residue
(residue number reindexed from 1)
H42 N55 W62 E65
Annotation score
4
Enzymatic activity
Enzyme Commision number
?
Gene Ontology
Molecular Function
GO:0005515
protein binding
GO:0016936
galactoside binding
GO:0030246
carbohydrate binding
Biological Process
GO:0043029
T cell homeostasis
GO:0043065
positive regulation of apoptotic process
GO:0050729
positive regulation of inflammatory response
GO:0098609
cell-cell adhesion
Cellular Component
GO:1990724
galectin complex
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Molecular Function
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Biological Process
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Cellular Component
External links
PDB
RCSB:1hlc
,
PDBe:1hlc
,
PDBj:1hlc
PDBsum
1hlc
PubMed
8262940
UniProt
P05162
|LEG2_HUMAN Galectin-2 (Gene Name=LGALS2)
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