Structure of PDB 1hlc Chain A Binding Site BS02

Receptor Information
>1hlc Chain A (length=129) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ELEVKNMDMKPGSTLKITGSIADGTDGFVINLGQGTDKLNLHFNPRFSES
TIVCNSLDGSNWGQEQREDHLCFSPGSEVKFTVTFESDKFKVKLPDGHEL
TFPNRLGHSHLSYLSVRGGFNMSSFKLKE
Ligand information
Ligand IDGAL
InChIInChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3+,4+,5-,6-/m1/s1
InChIKeyWQZGKKKJIJFFOK-FPRJBGLDSA-N
SMILES
SoftwareSMILES
CACTVS 3.370OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@H]1O
OpenEye OEToolkits 1.7.2C(C1C(C(C(C(O1)O)O)O)O)O
CACTVS 3.370OC[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
ACDLabs 12.01OC1C(O)C(OC(O)C1O)CO
OpenEye OEToolkits 1.7.2C([C@@H]1[C@@H]([C@@H]([C@H]([C@@H](O1)O)O)O)O)O
FormulaC6 H12 O6
Namebeta-D-galactopyranose;
beta-D-galactose;
D-galactose;
galactose
ChEMBLCHEMBL300520
DrugBank
ZINCZINC000002597049
PDB chain1hlc Chain C Residue 2 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1hlc X-ray crystal structure of the human dimeric S-Lac lectin, L-14-II, in complex with lactose at 2.9-A resolution.
Resolution2.9 Å
Binding residue
(original residue number in PDB)
H45 N58 W65 E68
Binding residue
(residue number reindexed from 1)
H42 N55 W62 E65
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0016936 galactoside binding
GO:0030246 carbohydrate binding
Biological Process
GO:0043029 T cell homeostasis
GO:0043065 positive regulation of apoptotic process
GO:0050729 positive regulation of inflammatory response
GO:0098609 cell-cell adhesion
Cellular Component
GO:1990724 galectin complex

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External links
PDB RCSB:1hlc, PDBe:1hlc, PDBj:1hlc
PDBsum1hlc
PubMed8262940
UniProtP05162|LEG2_HUMAN Galectin-2 (Gene Name=LGALS2)

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