Structure of PDB 1h8l Chain A Binding Site BS02

Receptor Information

>1h8l Chain A (length=380)

QAVQPVDFRHHHFSDMEIFLRRYANEYPSITRLYSVGKSVELRELYVMEI
SDNPGIHEAGEPEFKYIGNMHGNEVVGRELLLNLIEYLCKNFGTDPEVTD
LVQSTRIHIMPSMNPDGYEKSQEGDRGGTVGRNNSNNYDLNRNFPDQFFQ
VTDPPQPETLAVMSWLKTYPFVLSANLHGGSLVVNYPFDDDEQGIAIYSK
SPDDAVFQQLALSYSKENKKMYQGSPCKDLYPTEYFPHGITNGAQWYNVP
GGMQDWNYLNTNCFEVTIELGCVKYPKAEELPKYWEQNRRSLLQFIKQVH
RGIWGFVLDATDGRGILNATISVADINHPVTTYKDGDYWRLLVQGTYKVT
ASARGYDPVTKTVEVDSKGGVQVNFTLSRT

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 1h8l Chain A Residue 999

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1h8l The crystal structure of the inhibitor-complexed carboxypeptidase D domain II and the modeling of regulatory carboxypeptidases.
• Resolution: 2.6 Å
• Binding residue (original residue number in PDB): H74 E77 H181
• Binding residue (residue number reindexed from 1): H71 E74 H178
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 3.4.17.22: metallocarboxypeptidase D.

Gene Ontology

Molecular Function

• GO:0004180 carboxypeptidase activity
• GO:0004181 metallocarboxypeptidase activity
• GO:0008237 metallopeptidase activity
• GO:0008270 zinc ion binding
• GO:0046872 metal ion binding

Biological Process

• GO:0006508 proteolysis
• GO:0006518 peptide metabolic process
• GO:0016485 protein processing

Cellular Component

• GO:0005615 extracellular space
• GO:0016020 membrane

External links

• PDB: RCSB:1h8l, PDBe:1h8l, PDBj:1h8l
• PDBsum: 1h8l
• PubMed: 11278909
• UniProt: P83852|CBPD_LOPSP Carboxypeptidase D (Fragment) (Gene Name=CPD)