BioLiP

InChI=1S/C10H17N6O13P3/c11-10-13-7-4(8(19)14-10)12-2-16(7)9-6(18)5(17)3(28-9)1-27-32(25,26)29-31(23,24)15-30(20,21)22/h2-3,5-6,9,17-18H,1H2,(H,25,26)(H3,11,13,14,19)(H4,15,20,21,22,23,24)/t3-,5-,6-,9-/m1/s1

InChIKey

UQABYHGXWYXDTK-UUOKFMHZSA-N

SMILES

Software	SMILES
ACDLabs 10.04	O=P(O)(O)NP(=O)(O)OP(=O)(O)OCC3OC(n2cnc1c2N=C(N)NC1=O)C(O)C3O
OpenEye OEToolkits 1.5.0	c1nc2c(n1[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)O[P@@](=O)(NP(=O)(O)O)O)O)O)N=C(NC2=O)N
OpenEye OEToolkits 1.5.0	c1nc2c(n1C3C(C(C(O3)COP(=O)(O)OP(=O)(NP(=O)(O)O)O)O)O)N=C(NC2=O)N
CACTVS 3.341	NC1=Nc2n(cnc2C(=O)N1)[C@@H]3O[C@H](CO[P@@](O)(=O)O[P@@](O)(=O)N[P](O)(O)=O)[C@@H](O)[C@H]3O
CACTVS 3.341	NC1=Nc2n(cnc2C(=O)N1)[CH]3O[CH](CO[P](O)(=O)O[P](O)(=O)N[P](O)(O)=O)[CH](O)[CH]3O

Formula

C10 H17 N6 O13 P3

Name

PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER

PDB chain

1gua Chain A Residue 170 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Molecular Function

GO:0003924

GTPase activity

GO:0003925

G protein activity

GO:0005085

guanyl-nucleotide exchange factor activity

protein binding

GTP binding

hydrolase activity

GDP binding

small GTPase binding

protein-containing complex binding

	Biological Process
GO:0007165	signal transduction
GO:0007264	small GTPase-mediated signal transduction
GO:0007399	nervous system development
GO:0010976	positive regulation of neuron projection development
GO:0016079	synaptic vesicle exocytosis
GO:0030033	microvillus assembly
GO:0032486	Rap protein signal transduction
GO:0038180	nerve growth factor signaling pathway
GO:0043547	positive regulation of GTPase activity
GO:0045860	positive regulation of protein kinase activity
GO:0061028	establishment of endothelial barrier
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0071320	cellular response to cAMP
GO:0072659	protein localization to plasma membrane
GO:0098696	regulation of neurotransmitter receptor localization to postsynaptic specialization membrane
GO:1901888	regulation of cell junction assembly
GO:1990090	cellular response to nerve growth factor stimulus
GO:2000301	negative regulation of synaptic vesicle exocytosis
GO:2001214	positive regulation of vasculogenesis

Biological Process

GO:0007165

signal transduction

GO:0007264

small GTPase-mediated signal transduction

GO:0007399

nervous system development

GO:0010976

positive regulation of neuron projection development

GO:0016079

synaptic vesicle exocytosis

GO:0030033

microvillus assembly

GO:0032486

Rap protein signal transduction

GO:0038180

nerve growth factor signaling pathway

GO:0043547

positive regulation of GTPase activity

GO:0045860

positive regulation of protein kinase activity

GO:0061028

establishment of endothelial barrier

GO:0070374

positive regulation of ERK1 and ERK2 cascade

GO:0071320

cellular response to cAMP

GO:0072659

protein localization to plasma membrane

GO:0098696

regulation of neurotransmitter receptor localization to postsynaptic specialization membrane

GO:1901888

regulation of cell junction assembly

GO:1990090

cellular response to nerve growth factor stimulus

GO:2000301

negative regulation of synaptic vesicle exocytosis

GO:2001214

positive regulation of vasculogenesis

	Cellular Component
GO:0005737	cytoplasm
GO:0005768	endosome
GO:0005769	early endosome
GO:0005770	late endosome
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0010008	endosome membrane
GO:0016020	membrane
GO:0030054	cell junction
GO:0032045	guanyl-nucleotide exchange factor complex
GO:0035579	specific granule membrane
GO:0043005	neuron projection
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular exosome
GO:0070161	anchoring junction
GO:0097225	sperm midpiece
GO:0098793	presynapse
GO:0098978	glutamatergic synapse

Cellular Component

cytoplasm

endosome

early endosome

late endosome

cytosol