Structure of PDB 1ga6 Chain A Binding Site BS02

Receptor Information

>1ga6 Chain A (length=369) Species: 306 (Pseudomonas sp.)

AGTAKGHNPTEFPTIYDASSAPTAANTTVGIITIGGVSQTLQDLQQFTSA
NGLASVNTQTIQTGSSNGDYSDDQQGQGEWDLDSQSIVGSAGGAVQQLLF
YMADQSASGNTGLTQAFNQAVSDNVAKVINVSLGWCEADANADGTLQAED
RIFATAAAQGQTFSVSSGDEGVYECNNRGYPDGSTYSVSWPASSPNVIAV
GGTTLYTTSAGAYSNETVWNEGLDSNGKLWATGGGYSVYESKPSWQSVVS
GTPGRRLLPDISFDAAQGTGALIYNYGQLQQIGGTSLASPIFVGLWARLQ
SANSNSLGFPAASFYSAISSTPSLVHDVKSGNNGYGGYGYNAGTGWDYPT
GWGSLDIAKLSAYIRSNGF

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 1ga6 Chain A Residue 374

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1ga6 Carboxyl proteinase from Pseudomonas defines a novel family of subtilisin-like enzymes.
• Resolution: 1.0 Å
• Binding residue (original residue number in PDB): D328 V329 G344 G346 D348
• Binding residue (residue number reindexed from 1): D327 V328 G343 G345 D347
• Annotation score: 4

Enzymatic activity

• Catalytic site (original residue number in PDB): E80 D84 D170 S287
• Catalytic site (residue number reindexed from 1): E79 D83 D169 S286
• Enzyme Commision number: 3.4.21.100: sedolisin.

Gene Ontology

Molecular Function

• GO:0004252 serine-type endopeptidase activity
• GO:0008236 serine-type peptidase activity

Biological Process

• GO:0006508 proteolysis

External links

• PDB: RCSB:1ga6, PDBe:1ga6, PDBj:1ga6
• PDBsum: 1ga6
• PubMed: 11323721
• UniProt: P42790|PICP_PSESR Pseudomonalisin (Gene Name=pcp)