Structure of PDB 1ga1 Chain A Binding Site BS02

Receptor Information

>1ga1 Chain A (length=370) Species: 306 (Pseudomonas sp.)

GTAKGHNPTEFPTIYDASSAPTAANTTVGIITIGGVSQTLQDLQQFTSAN
GLASVNTQTIQTGSSNGDYSDDQQGQGEWDLDSQSIVGSAGGAVQQLLFY
MADQSASGNTGLTQAFNQAVSDNVAKVINVSLGWCEADANADGTLQAEDR
IFATAAAQGQTFSVSSGDEGVYECNNRGYPDGSTYSVSWPASSPNVIAVG
GTTLYTTSAGAYSNETVWNEGLDSNGKLWATGGGYSVYESKPSWQSVVSG
TPGRRLLPDISFDAAQGTGALIYNYGQLQQIGGTSLASPIFVGLWARLQS
ANSNSLGFPAASFYSAISSTPSLVHDVKSGNNGYGGYGYNAGTGWDYPTG
WGSLDIAKLSAYIRSNGFGH

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 1ga1 Chain A Residue 374

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1ga1 Practical experience with the use of halides for phasing macromolecular structures: a powerful tool for structural genomics.
• Resolution: 1.4 Å
• Binding residue (original residue number in PDB): D328 V329 G344 G346 D348
• Binding residue (residue number reindexed from 1): D326 V327 G342 G344 D346
• Annotation score: 4

Enzymatic activity

• Catalytic site (original residue number in PDB): E80 D84 D170 S287
• Catalytic site (residue number reindexed from 1): E78 D82 D168 S285
• Enzyme Commision number: 3.4.21.100: sedolisin.

Gene Ontology

Molecular Function

• GO:0004252 serine-type endopeptidase activity
• GO:0008236 serine-type peptidase activity

Biological Process

• GO:0006508 proteolysis

External links

• PDB: RCSB:1ga1, PDBe:1ga1, PDBj:1ga1
• PDBsum: 1ga1
• PubMed: 11173470
• UniProt: P42790|PICP_PSESR Pseudomonalisin (Gene Name=pcp)