Structure of PDB 1g8i Chain A Binding Site BS02

Receptor Information
>1g8i Chain A (length=182) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SNSKLKPEVVEELTRKTYFTEKEVQQWYKGFIKDCPSGQLDAAGFQKIYK
QFFPFGDPTKFATFVFNVFDENKDGRIEFSEFIQALSVTSRGTLDEKLRW
AFKLYDLDNDGYITRNEMLDIVDAIYQMVLPEEENTPEKRVDRIFAMMDK
NADGKLTLQEFQEGSKADPSIVQALSLYDGLV
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain1g8i Chain A Residue 1598 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1g8i Immunocytochemical localization and crystal structure of human frequenin (neuronal calcium sensor 1).
Resolution1.9 Å
Binding residue
(original residue number in PDB)		D109 D111 D113 Y115 E120
Binding residue
(residue number reindexed from 1)		D106 D108 D110 Y112 E117
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005245 voltage-gated calcium channel activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008048 calcium sensitive guanylate cyclase activator activity
GO:0046872 metal ion binding
Biological Process
GO:0010975 regulation of neuron projection development
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0014069 postsynaptic density
GO:0030424 axon
GO:0030425 dendrite
GO:0043231 intracellular membrane-bounded organelle
GO:0045202 synapse
GO:0048471 perinuclear region of cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1g8i, PDBe:1g8i, PDBj:1g8i
PDBsum1g8i
PubMed11092894
UniProtP62166|NCS1_HUMAN Neuronal calcium sensor 1 (Gene Name=NCS1)

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