Structure of PDB 1fx8 Chain A Binding Site BS02

Receptor Information
>1fx8 Chain A (length=254) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TLKGQCIAEFLGTGLLIFFGVGCVAALKVAGASFGQWEISVIWGLGVAMA
IYLTAGVSGAHLNPAVTIALWLFACFDKRKVIPFIVSQVAGAFCAAALVY
GLYYNLFFDFEQTHHIVRGSVESVDLAGTFSTYPNPHINFVQAFAVEMVI
TAILMGLILALTDDGNGVPRGPLAPLLIGLLIAVIGASMGPLTGFAMNPA
RDFGPKVFAWLAGWGNVAFTGGRDIPYFLVPLFGPIVGAIVGAFAYRKLI
GRHL
Ligand information
Ligand IDGOL
InChIInChI=1S/C3H8O3/c4-1-3(6)2-5/h3-6H,1-2H2
InChIKeyPEDCQBHIVMGVHV-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.0C(C(CO)O)O
ACDLabs 12.01
CACTVS 3.370		OCC(O)CO
FormulaC3 H8 O3
NameGLYCEROL;
GLYCERIN;
PROPANE-1,2,3-TRIOL
ChEMBLCHEMBL692
DrugBankDB09462
ZINCZINC000000895048
PDB chain1fx8 Chain A Residue 663 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1fx8 Structure of a glycerol-conducting channel and the basis for its selectivity.
Resolution2.2 Å
Binding residue
(original residue number in PDB)		N68 N203
Binding residue
(residue number reindexed from 1)		N63 N198
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005372 water transmembrane transporter activity
GO:0015168 glycerol transmembrane transporter activity
GO:0015254 glycerol channel activity
GO:0015267 channel activity
Biological Process
GO:0006833 water transport
GO:0015791 polyol transmembrane transport
GO:0015793 glycerol transmembrane transport
GO:0055085 transmembrane transport
GO:0071288 cellular response to mercury ion
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1fx8, PDBe:1fx8, PDBj:1fx8
PDBsum1fx8
PubMed11039922
UniProtP0AER0|GLPF_ECOLI Glycerol uptake facilitator protein (Gene Name=glpF)

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