Structure of PDB 1fqj Chain A Binding Site BS02

Receptor Information

>1fqj Chain A (length=317) Species: 9913,10116

RTVKLLLLGAGESGKSTIVKQMKIIHQDGYSLEECLEFIAIIYGNTLQSI
LAIVRAMTTLNIQYGDSARQDDARKLMHMADTIEEGTMPKEMSDIIQRLW
KDSGIQACFDRASEYQLNDSAGYYLSDLERLVTPGYVPTEQDVLRSRVKT
TGIIETQFSFKDLNFRMFDVGGQRSERKKWIHCFEGVTAIIFCVALSDYD
LVLAEDEEMNRMHESMKLFDSICNNKWFTDTSIILFLNKKDLFEEKIKKS
PLTICYPEYAGSNTYEEAGNYIKVQFLELNMRRDVKEIYSHMTCATDTQN
VKFVFDAVTDIIIKENL

Ligand information

• Ligand ID: ALF
• InChI: InChI=1S/Al.4FH/h;4*1H/q+3;;;;/p-4
• InChIKey: UYOMQIYKOOHAMK-UHFFFAOYSA-J
• SMILES:
  ACDLabs 10.04
  CACTVS 3.341
  OpenEye OEToolkits 1.5.0: F[Al-](F)(F)F
• Formula: Al F4
• Name: TETRAFLUOROALUMINATE ION
• DrugBank: DB04444
• PDB chain: 1fqj Chain A Residue 362

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1fqj Structural determinants for regulation of phosphodiesterase by a G protein at 2.0 A.
• Resolution: 2.02 Å
• Binding residue (original residue number in PDB): G38 E39 K42 R174 K176 T177 G199
• Binding residue (residue number reindexed from 1): G11 E12 K15 R147 K149 T150 G172
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): E39 T44 R174 D196 Q200
• Catalytic site (residue number reindexed from 1): E12 T17 R147 D169 Q173

Gene Ontology

Molecular Function

• GO:0003924 GTPase activity
• GO:0005525 GTP binding
• GO:0019001 guanyl nucleotide binding
• GO:0031683 G-protein beta/gamma-subunit complex binding

Biological Process

• GO:0007165 signal transduction
• GO:0007186 G protein-coupled receptor signaling pathway
• GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway

External links

• PDB: RCSB:1fqj, PDBe:1fqj, PDBj:1fqj
• PDBsum: 1fqj
• PubMed: 11234020
• UniProt: P04695|GNAT1_BOVIN Guanine nucleotide-binding protein G(t) subunit alpha-1 (Gene Name=GNAT1);
  P10824|GNAI1_RAT Guanine nucleotide-binding protein G(i) subunit alpha-1 (Gene Name=Gnai1)