Structure of PDB 1fjx Chain A Binding Site BS02

Receptor Information
>1fjx Chain A (length=327) Species: 726 (Haemophilus haemolyticus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MIEIKDKQLTGLRFIDLFAGLGGFRLALESCGAECVYSNEWDKYAQEVYE
MNFGEKPEGDITQVNEKTIPDHDILCAGFPCQAFSISGKQKGFEDSRGTL
FFDIARIVREKKPKVVFMENVKNFASHDNGNTLEVVKNTMNELDYSFHAK
VLNALDYGIPQKRERIYMICFRNDLNIQNFQFPKPFELNTFVKDLLLPDS
EVEHLVIDRKDLVMTNQEIEQTTPKTVRLGIVGKGGQGERIYSTRGIAIG
LSAYGGGIFAKTGGYLVNGKTRKLHPRECARVMGYPDSYKVHPSTSQAYK
QFGNSVVINVLQYIAYNIGSSLNFKPY
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1fjx Functional roles of the conserved threonine 250 in the target recognition domain of HhaI DNA methyltransferase.
Resolution2.26 Å
Binding residue
(original residue number in PDB)		F79 C81 S85 I86 S87 K89 E119 V121 K162 R165 T226 R228 Q237 R240 Y242 G250 S252 A253 Y254 G303 N304
Binding residue
(residue number reindexed from 1)		F79 C81 S85 I86 S87 K89 E119 V121 K162 R165 T226 R228 Q237 R240 Y242 G250 S252 A253 Y254 G303 N304
Binding affinityPDBbind-CN: Kd=1.4nM
Enzymatic activity
Enzyme Commision number 2.1.1.37: DNA (cytosine-5-)-methyltransferase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003886 DNA (cytosine-5-)-methyltransferase activity
GO:0008168 methyltransferase activity
Biological Process
GO:0009307 DNA restriction-modification system
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:1fjx, PDBe:1fjx, PDBj:1fjx
PDBsum1fjx
PubMed11102456
UniProtP05102|MTH1_HAEPH Type II methyltransferase M.HhaI (Gene Name=hhaIM)

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