Structure of PDB 1fcv Chain A Binding Site BS02

Receptor Information
>1fcv Chain A (length=324) Species: 7460 (Apis mellifera) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EFNVYWNVPTFMCHKYGLRFEEVSEKYGILQNWMDKFRGEEIAILYDPGM
FPALLKDPNGNVVARNGGVPQLGNLTKHLQVFRDHLINQIPDKSFPGVGV
IDFESWRPIFRQNWASLQPYKKLSVEVVRREHPFWDDQRVEQEAKRRFEK
YGQLFMEETLKAAKRMRPAANWGYYAYPYCYNLTPNQPSAQCEATTMQEN
DKMSWLFESEDVLLPSVYLRWNLTSGERVGLVGGRVKEALRIARQMTTSR
KKVLPYYWYKYQDRRDTDLSRADLEATLRKITDLGADGFIIWGSSDDINT
KAKCLQFREYLNNELGPAVKRIAL
Ligand information
Ligand IDGCU
InChIInChI=1S/C6H10O7/c7-1-2(8)4(5(10)11)13-6(12)3(1)9/h1-4,6-9,12H,(H,10,11)/t1-,2-,3+,4-,6-/m0/s1
InChIKeyAEMOLEFTQBMNLQ-WAXACMCWSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0[C@@H]1([C@@H]([C@H](O[C@@H]([C@@H]1O)O)C(=O)O)O)O
CACTVS 3.341O[C@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O)C(O)=O
OpenEye OEToolkits 1.5.0C1(C(C(OC(C1O)O)C(=O)O)O)O
CACTVS 3.341O[CH]1O[CH]([CH](O)[CH](O)[CH]1O)C(O)=O
ACDLabs 10.04O=C(O)C1OC(O)C(O)C(O)C1O
FormulaC6 H10 O7
Namealpha-D-glucopyranuronic acid;
alpha-D-glucuronic acid;
D-glucuronic acid;
glucuronic acid
ChEMBL
DrugBank
ZINCZINC000004213449
PDB chain1fcv Chain B Residue 3 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1fcv Crystal structure of hyaluronidase, a major allergen of bee venom.
Resolution2.65 Å
Binding residue
(original residue number in PDB)		W301 S303 S304
Binding residue
(residue number reindexed from 1)		W292 S294 S295
Annotation score4
Enzymatic activity
Catalytic site (original residue number in PDB) D111 E113 Y184 Y227 W301
Catalytic site (residue number reindexed from 1) D102 E104 Y175 Y218 W292
Enzyme Commision number 3.2.1.35: hyaluronoglucosaminidase.
Gene Ontology
Molecular Function
GO:0004415 hyalurononglucosaminidase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006952 defense response
GO:0030214 hyaluronan catabolic process
Cellular Component
GO:0005576 extracellular region

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1fcv, PDBe:1fcv, PDBj:1fcv
PDBsum1fcv
PubMed11080624
UniProtQ08169|HUGA_APIME Hyaluronidase

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