Structure of PDB 1f7u Chain A Binding Site BS02

Receptor Information
>1f7u Chain A (length=606) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ASTANMISQLKKLSIAEPAVAKDSHPDVNIVDLMRNYISQELSKISGVDS
SLIFPALEWTNTMERGDLLIPIPRLRIKGANPKDLAVQWAEKFPCGDFLE
KVEANGPFIQFFFNPQFLAKLVIPDILTRKEDYGSCKLVENKKVIIEFSS
PNIAKPFHAGHLRSTIIGGFLANLYEKLGWEVIRMNYLGDWGKQFGLLAV
GFERYGNEEALVKDPIHHLFDVYVRINKDIEEEGDSIPLEQSTNGKAREY
FKRMEDGDEEALKIWKRFREFSIEKYIDTYARLNIKYDVYSGESQVSKES
MLKAIDLFKEKGLTHEDKGAVLIDLTKFNKKLGKAIVQKSDGTTLYLTRD
VGAAMDRYEKYHFDKMIYVIASQQDLHAAQFFEILKQMGFEWAKDLQHVN
FGMVQGMSTRKGTVVFLDNILEETKEKMHEVMKKNENKYAQIEHPEEVAD
LVGISAVMIQDMQGKRINNYEFKWERMLSFEGDTGPYLQYAHSRLRSVER
NASGITQEKWINADFSLLKEPAAKLLIRLLGQYPDVLRNAIKTHEPTTVV
TYLFKLTHQVSSCYDVLWVAGQTEELATARLALYGAARQVLYNGMRLLGL
TPVERM
Ligand information
Ligand IDARG
InChIInChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1
InChIKeyODKSFYDXXFIFQN-BYPYZUCNSA-O
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(CC(C(=O)O)N)CNC(=[NH2+])N
CACTVS 3.341N[C@@H](CCCNC(N)=[NH2+])C(O)=O
OpenEye OEToolkits 1.5.0C(C[C@@H](C(=O)O)N)CNC(=[NH2+])N
CACTVS 3.341N[CH](CCCNC(N)=[NH2+])C(O)=O
ACDLabs 10.04O=C(O)C(N)CCCN\C(=[NH2+])N
FormulaC6 H15 N4 O2
NameARGININE
ChEMBL
DrugBank
ZINC
PDB chain1f7u Chain A Residue 800 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1f7u tRNA aminoacylation by arginyl-tRNA synthetase: induced conformations during substrates binding
Resolution2.2 Å
Binding residue
(original residue number in PDB)		E148 S151 N153 Y188 Y347 D351 Y369 I371
Binding residue
(residue number reindexed from 1)		E147 S150 N152 Y187 Y346 D350 Y368 I370
Annotation score5
Enzymatic activity
Catalytic site (original residue number in PDB) K156 H159 H162
Catalytic site (residue number reindexed from 1) K155 H158 H161
Enzyme Commision number 6.1.1.19: arginine--tRNA ligase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004814 arginine-tRNA ligase activity
GO:0005524 ATP binding
GO:1990825 sequence-specific mRNA binding
Biological Process
GO:0006412 translation
GO:0006418 tRNA aminoacylation for protein translation
GO:0006420 arginyl-tRNA aminoacylation
GO:0032543 mitochondrial translation
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol

View graph for
Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:1f7u, PDBe:1f7u, PDBj:1f7u
PDBsum1f7u
PubMed11060012
UniProtQ05506|SYRC_YEAST Arginine--tRNA ligase, cytoplasmic (Gene Name=YDR341C)

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