Structure of PDB 1f5s Chain A Binding Site BS02

Receptor Information

>1f5s Chain A (length=210) Species: 2190 (Methanocaldococcus jannaschii)

EKKKKLILFDFDSTLVNNETIDEIAREAGVEEEVKKITKEAMEGKLNFEQ
SLRKRVSLLKDLPIEKVEKAIKRITPTEGAEETIKELKNRGYVVAVVSGG
FDIAVNKIKEKLGLDYAFANRLIVKDGKLTGDVEGEVLKENAKGEILEKI
AKIEGINLEDTVAVGDGANDISMFKKAGLKIAFCAKPILKEKADICIEKR
DLREILKYIK

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 1f5s Chain A Residue 221

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1f5s Crystal structure of phosphoserine phosphatase from Methanococcus jannaschii, a hyperthermophile, at 1.8 A resolution.
• Resolution: 1.8 Å
• Binding residue (original residue number in PDB): D11 D13 D167
• Binding residue (residue number reindexed from 1): D10 D12 D166
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): D11 F12 D13 G100 K144 D171
• Catalytic site (residue number reindexed from 1): D10 F11 D12 G99 K143 D170
• Enzyme Commision number: 3.1.3.3: phosphoserine phosphatase.

Gene Ontology

Molecular Function

• GO:0000287 magnesium ion binding
• GO:0016787 hydrolase activity
• GO:0036424 L-phosphoserine phosphatase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006564 L-serine biosynthetic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:1f5s, PDBe:1f5s, PDBj:1f5s
• PDBsum: 1f5s
• PubMed: 11342136
• UniProt: Q58989|SERB_METJA Phosphoserine phosphatase (Gene Name=MJ1594)