Structure of PDB 1f26 Chain A Binding Site BS02

Receptor Information
>1f26 Chain A (length=399) Species: 5507 (Fusarium oxysporum) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
APSFPFSRASGPEPPAEFAKLRATNPVSQVKLFDGSLAWLVTKHKDVCFV
ATSEKLSKVRTRQGFPELSASGKQAAKAKPTFVDMDPPEHMHQRSMVEPT
FTPEAVKNLQPYIQRTVDDLLEQMKQKGCANGPVDLVKEFALPVPSYIIY
TLLGVPFNDLEYLTQQNAIRTNGSSTAREASAANQELLDYLAILVEQRLV
EPKDDIISKLCTEQVKPGNIDKSDAVQIAFLLLVAGNAVMVNMIALGVAT
LAQHPDQLAQLKANPSLAPQFVEELCRYHTASALAIKRTAKEDVMIGDKL
VRANEGIIASNQSANRDEEVFENPDEFNMNRKWPPQDPLGFGFGDHRCIA
EHLAKAELTTVFSTLYQKFPDLKVAVPLGKINYTPLNRDVGIVDLPVIF
Ligand information
Ligand IDNO
InChIInChI=1S/HNO/c1-2/h1H
InChIKeyODUCDPQEXGNKDN-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.385
OpenEye OEToolkits 2.0.7		[N]=O
FormulaN O
NameNITRIC OXIDE;
Nitrogen monoxide
ChEMBLCHEMBL1234765
DrugBank
ZINC
PDB chain1f26 Chain A Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1f26 Mutation effects of a conserved threonine (Thr243) of cytochrome P450nor on its structure and function.
Resolution1.4 Å
Binding residue
(original residue number in PDB)		A239 G240
Binding residue
(residue number reindexed from 1)		A235 G236
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) T175 A239 A242 V243 M244 S286 C352 I353 A354 E361 D393
Catalytic site (residue number reindexed from 1) T171 A235 A238 V239 M240 S282 C348 I349 A350 E357 D389
Enzyme Commision number 1.7.1.14: nitric oxide reductase [NAD(P)(+), nitrous oxide-forming].
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 heme binding
GO:0046872 metal ion binding
GO:0102199 nitric oxide reductase (NAD(P)H) activity

View graph for
Molecular Function
External links
PDB RCSB:1f26, PDBe:1f26, PDBj:1f26
PDBsum1f26
PubMed11132616
UniProtP23295|NOR_FUSOX NADP nitrous oxide-forming nitric oxide reductase (Gene Name=CYP55A1)

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