Structure of PDB 1e6u Chain A Binding Site BS02

Receptor Information
>1e6u Chain A (length=315) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AKQRVFIAGHRGMVGSAIRRQLEQRGDVELVLRTRDELNLLDSRAVHDFF
ASERIDQVYLAAAKVGGIVANNTYPADFIYQNMMIESNIIHAAHQNDVNK
LLFLGSSCIYPKLAKQPMAESELLQGTLEPTNEPYAIAKIAGIKLCESYN
RQYGRDYRSVMPTNLYGPHDNFHPSNSHVIPALLRRFHEATAQKAPDVVV
WGSGTPMREFLHVDDMAAASIHVMELAHEVWLENTQPMLSHINVGTGVDC
TIRELAQTIAKVVGYKGRVVFDASKPDGTPRKLLDVTRLHQLGWYHEISL
EAGLASTYQWFLENQ
Ligand information
Ligand IDUVW
InChIInChI=1S/C2H5O5P/c1-2(3)7-8(4,5)6/h1H3,(H2,4,5,6)
InChIKeyLIPOUNRJVLNBCD-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341CC(=O)O[P](O)(O)=O
OpenEye OEToolkits 1.5.0CC(=O)OP(=O)(O)O
ACDLabs 10.04O=C(OP(=O)(O)O)C
FormulaC2 H5 O5 P
NameACETYLPHOSPHATE
ChEMBL
DrugBankDB02897
ZINCZINC000003869379
PDB chain1e6u Chain A Residue 1318 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1e6u Probing the Catalytic Mechanism of Gdp-4-Keto-6-Deoxy-D-Mannose Epimerase/Reductase by Kinetic and Crystallographic Characterization of Site-Specific Mutants
Resolution1.45 Å
Binding residue
(original residue number in PDB)		G68 I69 V70 A71 S178
Binding residue
(residue number reindexed from 1)		G67 I68 V69 A70 S177
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) S107 S108 C109 Y136 K140 H179
Catalytic site (residue number reindexed from 1) S106 S107 C108 Y135 K139 H178
Enzyme Commision number 1.1.1.271: GDP-L-fucose synthase.
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity
GO:0016853 isomerase activity
GO:0042803 protein homodimerization activity
GO:0050577 GDP-L-fucose synthase activity
GO:0070401 NADP+ binding
Biological Process
GO:0009226 nucleotide-sugar biosynthetic process
GO:0009242 colanic acid biosynthetic process
GO:0042351 'de novo' GDP-L-fucose biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1e6u, PDBe:1e6u, PDBj:1e6u
PDBsum1e6u
PubMed11021971
UniProtP32055|FCL_ECOLI GDP-L-fucose synthase (Gene Name=fcl)

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