Structure of PDB 1dxw Chain A Binding Site BS02

Receptor Information

>1dxw Chain A (length=165) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

TGRDKNQVEGEVQVVSTATQSFLATCVNGVCWTVYHGAGSKTLAGPKGPI
TQMYTNVDQDLVGWQAPPGARSLTPCTCGSSDLYLVTRHADVIPVRRRGD
SRGSLLSPRPVSYLKGSSGGPLLCPSGHAVGIFRAAVCTRGVAKAVDFVP
VESMETTMRASKKKK

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

1dxw Chain A Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	1dxw Inhibitor Binding Induces Active Site Stabilisation of the Hcv Ns3 Protein Serine Protease Domain
Resolution	N/A
Binding residue (original residue number in PDB)	C97 C99 C145 H149
Binding residue (residue number reindexed from 1)	C76 C78 C124 H128
Annotation score	1

Enzymatic activity

Catalytic site (original residue number in PDB)	H57 D81 G137 S139
Catalytic site (residue number reindexed from 1)	H36 D60 G116 S118
Enzyme Commision number	3.6.4.13: RNA helicase.

Gene Ontology

	Molecular Function
GO:0008236	serine-type peptidase activity
GO:0016787	hydrolase activity

	Biological Process
GO:0006508	proteolysis
GO:0019062	virion attachment to host cell
GO:0019087	transformation of host cell by virus
GO:0046718	symbiont entry into host cell

	Cellular Component
GO:0016020	membrane
GO:0033644	host cell membrane
GO:0044423	virion component

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Cellular Component

External links

PDB	RCSB:1dxw, PDBe:1dxw, PDBj:1dxw
PDBsum	1dxw
PubMed	10716920
UniProt	Q8QW30

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