Structure of PDB 1dsy Chain A Binding Site BS02

Receptor Information
>1dsy Chain A (length=137) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TEKRGRIYLKAEVTDEKLHVTVRDAKNLIPMDPNGLSDPYVKLKLIPDPK
NESKQKTKTIRSTLNPQWNESFTFKLKPSDKDRRLSVEIWDWDRTTRNDF
MGSLSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPE
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain1dsy Chain A Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1dsy Ca(2+) bridges the C2 membrane-binding domain of protein kinase Calpha directly to phosphatidylserine.
Resolution2.6 Å
Binding residue
(original residue number in PDB)		D187 D193 D246 W247 D248
Binding residue
(residue number reindexed from 1)		D32 D38 D91 W92 D93
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.11.13: protein kinase C.
External links
PDB RCSB:1dsy, PDBe:1dsy, PDBj:1dsy
PDBsum1dsy
PubMed10562545
UniProtP05696|KPCA_RAT Protein kinase C alpha type (Gene Name=Prkca)

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