Structure of PDB 1djw Chain A Binding Site BS02

Receptor Information
>1djw Chain A (length=513) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EIETFYKMLTQRAEIDRAFEEAAGSAETLSVERLVTFLQHQQREEEAGPA
LALSLIERYEPSETAKAQRQMTKDGFLMYLLSADGNAFSLAHRRVYQDMD
QPLSHYLVSSSHNTYLLEDQLTGPSSTEAYIRALCKGCRCLELDCWDGPN
QEPIIYHGYTFTSKILFCDVLRAIRDYAFKASPYPVILSLENHCSLEQQR
VMARHLRAILGPILLDQPLDGVTTSLPSPEQLKGKILLKGKKLKLVPELS
DMIIYCKSVHFGGFSSPGTSGQAFYEMASFSESRALRLLQESGNGFVRHN
VSCLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYLGCF
QDNGGCGYVLKPAFLRDPNTTFNSRALTQGPWWRPERLRVRIISGQQLPK
VNKNKNSIVDPKVIVEIHGVGRDTGSRQTAVITNNGFNPRWDMEFEFEVT
VPDLALVRFMVEDYDSSSKNDFIGQSTIPWNSLKQGYRHVHLLSKNGDQH
PSATLFVKISIQD
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain1djw Chain A Residue 3 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1djw Structural mapping of the catalytic mechanism for a mammalian phosphoinositide-specific phospholipase C.
Resolution2.45 Å
Binding residue
(original residue number in PDB)		I651 D653 N677
Binding residue
(residue number reindexed from 1)		I408 D410 N434
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) H311 N312 E341 D343 H356 E390
Catalytic site (residue number reindexed from 1) H112 N113 E142 D144 H157 E191
Enzyme Commision number 3.1.4.11: phosphoinositide phospholipase C.
Gene Ontology
Molecular Function
GO:0004435 phosphatidylinositol phospholipase C activity
GO:0005509 calcium ion binding
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0006629 lipid metabolic process
GO:0007165 signal transduction
GO:0035556 intracellular signal transduction

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1djw, PDBe:1djw, PDBj:1djw
PDBsum1djw
PubMed9048554
UniProtP10688|PLCD1_RAT 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 (Gene Name=Plcd1)

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