Structure of PDB 1dew Chain A Binding Site BS02

Receptor Information
>1dew Chain A (length=278) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GPALYEDPPDHKTSPSGKPATLKICSWNVDGLRAWIKKKGLDWVKEEAPD
ILCLQETKCSENKLPAELQELPGLSHQYWSAPSDKEGYSGVGLLSRQCPL
KVSYGIGDEEHDQEGRVIVAEFDSFVLVTAYVPNAGRGLVRLEYRQRWDE
AFRKFLKGLASRKPLVLCGDLNVAHEEIDLRNPKGNKKNAGFTPQERQGF
GELLQAVPLADSFRHLYPNTPYAYTFWTYMMNARSKNVGWRLDYFLLSHS
LLPALCDSKIRSKALGSDHCPITLYLAL
Ligand information
Receptor-Ligand Complex Structure
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PDB1dew DNA-bound structures and mutants reveal abasic DNA binding by APE1 and DNA repair coordination
Resolution2.65 Å
Binding residue
(original residue number in PDB)		G71 R73 A74 K78 E126 G127 K224 Y269 M270 M271
Binding residue
(residue number reindexed from 1)		G31 R33 A34 K38 E86 G87 K184 Y229 M230 M231
Enzymatic activity
Catalytic site (original residue number in PDB) D70 E96 N212 D283 D308
Catalytic site (residue number reindexed from 1) D30 E56 N172 D243 D268
Enzyme Commision number 3.1.11.2: exodeoxyribonuclease III.
3.1.21.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003824 catalytic activity
GO:0004518 nuclease activity
GO:0004519 endonuclease activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:1dew, PDBe:1dew, PDBj:1dew
PDBsum1dew
PubMed10667800
UniProtP27695|APEX1_HUMAN DNA repair nuclease/redox regulator APEX1 (Gene Name=APEX1)

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