Structure of PDB 1dd4 Chain A Binding Site BS02

Receptor Information

>1dd4 Chain A (length=128) Species: 2336 (Thermotoga maritima)

MTIDEIIEAIEKLTVSELAELVKKLEDKFGVTAAAPVAVAAAPVAGAAAG
AAQEEKTEFDVVLKSFGQNKIQVIKVVREITGLGLKEAKDLVEKAGSPDA
VIKSGVSKEEAEEIKKKLEEAGAEVELK

Ligand information

• Ligand ID: TBR
• InChI: InChI=1S/12BrH.6Ta/h12*1H;;;;;;/q;;;;;;;;;;;;;;;;;+1/p-1
• InChIKey: YWYIQTPPCOBSGN-UHFFFAOYSA-M
• SMILES:
  OpenEye OEToolkits 1.7.0: Br[Ta]123456Br[Ta]17891%10[Ta]22%11(Br7)[Ta]337%12%13([Ta]484([Ta]923(Br%11)(Br1)(Br4)(Br7)Br%12)(Br5)(Br%10)Br%13)Br6
  CACTVS 3.370: Br|1[Ta]|2|3|4|5|Br[Ta]|6|7|89%10|2|Br[Ta]|%11|%12|%13|%14|1|3|6Br|[Ta]|%15|%16|%17|7|%11(Br|[Ta]|%18|4|%12|%15(Br|%13)(Br|%14)|Br[Ta]|5|8|%16|%18(|Br9)(Br)Br|%17)|Br%10
• Formula: Br12 Ta6
• Name: HEXATANTALUM DODECABROMIDE;
  DODECABROMOHEXATANTALUM
• DrugBank: DB04119
• PDB chain: 1dd4 Chain A Residue 402

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1dd4 Flexibility, conformational diversity and two dimerization modes in complexes of ribosomal protein L12.
• Resolution: 2.4 Å
• Binding residue (original residue number in PDB): K103 E110
• Binding residue (residue number reindexed from 1): K103 E110
• Annotation score: 1

Gene Ontology

Molecular Function

• GO:0003729 mRNA binding
• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:1dd4, PDBe:1dd4, PDBj:1dd4
• PDBsum: 1dd4
• PubMed: 10637222
• UniProt: P29396|RL7_THEMA Large ribosomal subunit protein bL12 (Gene Name=rplL)