Structure of PDB 1cwt Chain A Binding Site BS02

Receptor Information
>1cwt Chain A (length=177) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DHRELIGDYSKAFLLQTVDGKHQDLKYISPETMVALLTGKFSNIVDKFVI
VDCRYPYEYEGGHIKTAVNLPLERDAESFLLKSPIAPCSLDKRVILIFHC
EFSSERGPRMCRFIRERDRAVNDYPSLYYPEMYILKGGYKEFFPQHPNFC
EPQDYRPMNHEAFKDELKTFRLKTRSW
Ligand information
Ligand IDSO4
InChIInChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2
InChIKeyQAOWNCQODCNURD-UHFFFAOYSA-L
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0[O-]S(=O)(=O)[O-]
CACTVS 3.341[O-][S]([O-])(=O)=O
ACDLabs 10.04[O-]S([O-])(=O)=O
FormulaO4 S
NameSULFATE ION
ChEMBL
DrugBankDB14546
ZINC
PDB chain1cwt Chain A Residue 553 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1cwt Crystal structure of the catalytic subunit of Cdc25B required for G2/M phase transition of the cell cycle.
Resolution2.3 Å
Binding residue
(original residue number in PDB)		R488 R492
Binding residue
(residue number reindexed from 1)		R115 R119
Annotation score1
Enzymatic activity
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:1902751 positive regulation of cell cycle G2/M phase transition

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Molecular Function
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Biological Process
External links
PDB RCSB:1cwt, PDBe:1cwt, PDBj:1cwt
PDBsum1cwt
PubMed10543950
UniProtP30305|MPIP2_HUMAN M-phase inducer phosphatase 2 (Gene Name=CDC25B)

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