Structure of PDB 1cws Chain A Binding Site BS02

Receptor Information
>1cws Chain A (length=178) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SDHRELIGDYSKAFLLQTVDGKHQDLKYISPETMVALLTGKFSNIVDKFV
IVDCRYPYEYEGGHIKTAVNLPLERDAESFLLKSPIAPCSLDKRVILIFH
CEFSSERGPRMCRFIRERDRAVNDYPSLYYPEMYILKGGYKEFFPQHPNF
CEPQDYRPMNHEAFKDELKTFRLKTRSW
Ligand information
Ligand IDCL
InChIInChI=1S/ClH/h1H/p-1
InChIKeyVEXZGXHMUGYJMC-UHFFFAOYSA-M
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[Cl-]
FormulaCl
NameCHLORIDE ION
ChEMBL
DrugBankDB14547
ZINC
PDB chain1cws Chain A Residue 569 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1cws Crystal structure of the catalytic subunit of Cdc25B required for G2/M phase transition of the cell cycle.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		L445 E446 T547 R548
Binding residue
(residue number reindexed from 1)		L73 E74 T175 R176
Annotation score1
Enzymatic activity
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:1902751 positive regulation of cell cycle G2/M phase transition

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Molecular Function
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Biological Process
External links
PDB RCSB:1cws, PDBe:1cws, PDBj:1cws
PDBsum1cws
PubMed10543950
UniProtP30305|MPIP2_HUMAN M-phase inducer phosphatase 2 (Gene Name=CDC25B)

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