Structure of PDB 1cjy Chain A Binding Site BS02

Receptor Information
>1cjy Chain A (length=633) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EHQYSHKFTVVVLRATKVTKGAFGDMLDTPDPYVELFISTTPDSRKRTRH
FNNDINPVWNETFEFILDPNQENVLEITLMDANYVMDETLGTATFTVSSM
KVGEKKEVPFIFNQVTEMVLEMSLEVCSCPDLRFSMALCDQEKTFRQQRK
EHIRESMKKLLGPKNSEGLHSARDVPVVAILGSGGGFRAMVGFSGVMKAL
YESGILDCATYVAGLSGSTWYMSTLYSHPDFPEKGPEEINEELMKNVSHN
PLLLLTPQKVKRYVESLWKKKSSGQPVTFTDIFGMLIGETLIHNRMNTTL
SSLKEKVNTAQCPLPLFTCLHVKPDVSELMFADWVEFSPYEIGMAKYGTF
MAPDLFGSKFFMGTVVKKYEENPLHFLMGVWGSAFSILFNRVLSTMEEEL
ENITTKHIVSNNQASWIHRMIMALVSDSALFNTREGRAGKVHNFMLGLNL
DVKSKKIHVVDSGLTFNLPYPLILRPQRGVDLIISFDFSARPSDSSPPFK
ELLLAEKWAKMNKLPFPKIDPYVFDREGLKECYVFKPKNPDMEKDCPTII
HFVLANINFRKYKAPGVPRETEEEKEIADFDIFDDPESPFSTFNFQYPNQ
AFKRLHDLMHFNTLNNIDVIKEAMVESIEYRRQ
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain1cjy Chain A Residue 951 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1cjy Crystal structure of human cytosolic phospholipase A2 reveals a novel topology and catalytic mechanism.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		D40 D43 D93 A94 N95
Binding residue
(residue number reindexed from 1)		D28 D31 D81 A82 N83
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) G197 G198 R200 S228 D549
Catalytic site (residue number reindexed from 1) G185 G186 R188 S216 D461
Enzyme Commision number 3.1.1.4: phospholipase A2.
3.1.1.5: lysophospholipase.
Gene Ontology
Molecular Function
GO:0004620 phospholipase activity
GO:0004622 lysophospholipase activity
GO:0004623 phospholipase A2 activity
GO:0005509 calcium ion binding
GO:0005544 calcium-dependent phospholipid binding
GO:0008289 lipid binding
GO:0008374 O-acyltransferase activity
GO:0010314 phosphatidylinositol-5-phosphate binding
GO:0016787 hydrolase activity
GO:0032266 phosphatidylinositol-3-phosphate binding
GO:0046872 metal ion binding
GO:0047498 calcium-dependent phospholipase A2 activity
GO:0047499 calcium-independent phospholipase A2 activity
GO:0070273 phosphatidylinositol-4-phosphate binding
GO:1902387 ceramide 1-phosphate binding
Biological Process
GO:0001516 prostaglandin biosynthetic process
GO:0002827 positive regulation of T-helper 1 type immune response
GO:0006071 glycerol metabolic process
GO:0006640 monoacylglycerol biosynthetic process
GO:0006650 glycerophospholipid metabolic process
GO:0006663 platelet activating factor biosynthetic process
GO:0006690 icosanoid metabolic process
GO:0009395 phospholipid catabolic process
GO:0010572 positive regulation of platelet activation
GO:0019369 arachidonate metabolic process
GO:0019370 leukotriene biosynthetic process
GO:0032308 positive regulation of prostaglandin secretion
GO:0034478 phosphatidylglycerol catabolic process
GO:0034638 phosphatidylcholine catabolic process
GO:0036151 phosphatidylcholine acyl-chain remodeling
GO:0042127 regulation of cell population proliferation
GO:0043032 positive regulation of macrophage activation
GO:0046456 icosanoid biosynthetic process
GO:0046475 glycerophospholipid catabolic process
GO:0050482 arachidonate secretion
GO:0051649 establishment of localization in cell
GO:0071236 cellular response to antibiotic
Cellular Component
GO:0000139 Golgi membrane
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005737 cytoplasm
GO:0005743 mitochondrial inner membrane
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0016020 membrane
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1cjy, PDBe:1cjy, PDBj:1cjy
PDBsum1cjy
PubMed10319815
UniProtP47712|PA24A_HUMAN Cytosolic phospholipase A2 (Gene Name=PLA2G4A)

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