Structure of PDB 1cdk Chain A Binding Site BS02
Receptor Information
>1cdk Chain A (length=343) Species:
9823
(Sus scrofa) [
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KGSEQESVKEFLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRV
MLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLE
YSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYL
HSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAP
EIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRF
PSHFSSDLKDLLRNLLQVDLTKRFGNLKDGVNDIKNHKWFATTDWIAIYQ
RKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF
Ligand information
Ligand ID
MN
InChI
InChI=1S/Mn/q+2
InChIKey
WAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
Software
SMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0
[Mn+2]
CACTVS 3.341
[Mn++]
Formula
Mn
Name
MANGANESE (II) ION
ChEMBL
DrugBank
DB06757
ZINC
PDB chain
1cdk Chain A Residue 401 [
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Receptor-Ligand Complex Structure
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PDB
1cdk
Phosphotransferase and substrate binding mechanism of the cAMP-dependent protein kinase catalytic subunit from porcine heart as deduced from the 2.0 A structure of the complex with Mn2+ adenylyl imidodiphosphate and inhibitor peptide PKI(5-24).
Resolution
2.0 Å
Binding residue
(original residue number in PDB)
N171 D184
Binding residue
(residue number reindexed from 1)
N164 D177
Annotation score
1
Enzymatic activity
Catalytic site (original residue number in PDB)
D166 K168 E170 N171 D184 T201
Catalytic site (residue number reindexed from 1)
D159 K161 E163 N164 D177 T194
Enzyme Commision number
2.7.11.11
: cAMP-dependent protein kinase.
Gene Ontology
Molecular Function
GO:0004672
protein kinase activity
GO:0004674
protein serine/threonine kinase activity
GO:0004679
AMP-activated protein kinase activity
GO:0004691
cAMP-dependent protein kinase activity
GO:0005524
ATP binding
GO:0034237
protein kinase A regulatory subunit binding
GO:0106310
protein serine kinase activity
Biological Process
GO:0006468
protein phosphorylation
GO:0010737
protein kinase A signaling
GO:0016310
phosphorylation
GO:0034605
cellular response to heat
GO:1904145
negative regulation of meiotic cell cycle process involved in oocyte maturation
GO:1904262
negative regulation of TORC1 signaling
Cellular Component
GO:0001669
acrosomal vesicle
GO:0005634
nucleus
GO:0005737
cytoplasm
GO:0005739
mitochondrion
GO:0005829
cytosol
GO:0005886
plasma membrane
GO:0005952
cAMP-dependent protein kinase complex
GO:0036126
sperm flagellum
GO:0042585
germinal vesicle
GO:0048471
perinuclear region of cytoplasm
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Molecular Function
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Biological Process
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Cellular Component
External links
PDB
RCSB:1cdk
,
PDBe:1cdk
,
PDBj:1cdk
PDBsum
1cdk
PubMed
8384554
UniProt
P36887
|KAPCA_PIG cAMP-dependent protein kinase catalytic subunit alpha (Gene Name=PRKACA)
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