Structure of PDB 1bf5 Chain A Binding Site BS02

Receptor Information
>1bf5 Chain A (length=545) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LDKQKELDSKVRNVKDKVMCIEHEIKSLEDLQDEYDFKCKTLQNREHLLL
KKMYLMLDNKRKEVVHKIIELLNVTELTQNALINDELVEWKRRQQSACIG
GPPNACLDQLQNWFTIVAESLQQVRQQLKKLEELEQKYTYEHDPITKNKQ
VLWDRTFSLFQQLIQSSFVVERQPCMPTHPQRPLVLKTGVQFTVKLRLLV
KLQELNYNLKVKVLFDKDVNERNTVKGFRKFNILGTHTKVMNMEESTNGS
LAAEFRHLQLKEQKNAGTRTNEGPLIVTEELHSLSFETQLCQPGLVIDLE
TTSLPVVVISNVSQLPSGWASILWYNMLVAEPRNLSFFLTPPCARWAQLS
EVLSWQFSSVTKRGLNVDQLNMLGEKLLGPNASPDGLIPWTRFCKENIND
KNFPFWLWIESILELIKKHLLPLWNDGCIMGFISKERERALLKDQQPGTF
LLRFSESSREGAITFTWVERSQNGGEPDFHAVEPYTKKELSAVTFPDIIR
NYKVMAAENIPENPLKYLYPNIDKDHAFGKYYSRGYIKTELISVS
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB1bf5 Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		R378 K413 E421 V426 T427 S459 N460 Q463
Binding residue
(residue number reindexed from 1)		R229 K264 E272 V277 T278 S310 N311 Q314
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0007165 signal transduction

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1bf5, PDBe:1bf5, PDBj:1bf5
PDBsum1bf5
PubMed9630226
UniProtP42224|STAT1_HUMAN Signal transducer and activator of transcription 1-alpha/beta (Gene Name=STAT1)

[Back to BioLiP]